Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier.
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier.
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DOI：
10.4161/mabs.3.2.14239
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发表时间：
2011-03
期刊：
影响因子：
5.3
通讯作者：
Lampson LA
中科院分区：
文献类型：
--
作者：
Lampson LA
单克隆抗体（mab）用于治疗许多肿瘤的成功率越来越高，但对于脑肿瘤，血脑屏障（BBB）是一个特别关注的问题。血脑屏障阻止抗体进入正常大脑；然而，它在脑肿瘤治疗中的作用更为复杂。微肿瘤部位血脑屏障最接近正常；它的性质和重要性随着肿瘤的生长而变化。在本综述中，当单克隆抗体用于脑肿瘤靶点时，对血脑屏障作用的不断发展的见解与影响疗效或解释的其他因素相平衡。作为具体的例子，我们分别在治疗的背景下讨论了多型胶质母细胞瘤（GBM）、原发性中枢神经系统淋巴瘤（PCNSL）和乳腺癌血源性转移瘤，这些单克隆抗体分别是贝伐单抗、利妥昔单抗和曲妥珠单抗，它们已经被广泛用于治疗脑外肿瘤。有人建议，成功对抗脑肿瘤需要在两个方面突破血脑屏障：物理上，更好地攻击脑肿瘤目标；概念上，给予与其他肿瘤部位相同的问题同样的关注。
Monoclonal antibodies (mAbs) are used with increasing success against many tumors, but for brain tumors the blood-brain barrier (BBB) is a special concern. The BBB prevents antibody entry to the normal brain; however, its role in brain tumor therapy is more complex. The BBB is closest to normal at micro-tumor sites; its properties and importance change as the tumor grows. In this review, evolving insight into the role of the BBB is balanced against other factors that affect efficacy or interpretation when mAbs are used against brain tumor targets. As specific examples, glioblastoma multiforme (GBM), primary central nervous system lymphoma (PCNSL) and blood-borne metastases from breast cancer are discussed in the context of treatment, respectively, with the mAbs bevacizumab, rituximab and trastuzumab, each of which is already widely used against tumors outside the brain. It is suggested that success against brain tumors will require getting past the BBB in two senses: physically, to better attack brain tumor targets, and conceptually, to give equal attention to problems that are shared with other tumor sites.
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影响因子：
12.7
作者：
AHO, R;EKFORS, T;KALIMO, H
通讯作者：
KALIMO, H
影响因子：
13.5
作者：
Eyal, Sara;Hsiao, Peng;Unadkat, Jashvant D.
通讯作者：
Unadkat, Jashvant D.
影响因子：
9.9
作者：
Dalakas, Marinos C.
通讯作者：
Dalakas, Marinos C.
影响因子：
3.9
作者：
Church, D. N.;Bahl, A.;Price, C. G. A.
通讯作者：
Price, C. G. A.
DOI：
10.1056/nejmoa0706383
发表时间：
2008-02-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hauser, Stephen L;Waubant, Emmanuelle;Smith, Craig H
通讯作者：
Smith, Craig H