Brain processing of the mammary pheromone in newborn rabbits
Brain processing of the mammary pheromone in newborn rabbits
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DOI：
10.1016/j.bbr.2011.09.008
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发表时间：
2012-01-01
影响因子：
2.7
通讯作者：
Coureaud, G.
中科院分区：
文献类型：
--
作者：
Charra, R.;Datiche, F.;Coureaud, G.
化学信号对哺乳动物的社会互动有很大贡献，包括母幼关系。在欧洲兔子中，已分离出哺乳期雌性兔子在牛奶中释放的挥发性化合物 2-甲基丁-2-烯醛。它具有信息素的特性，特别是新生儿释放关键吸吮相关运动的自发能力，被称为乳腺信息素 (MP)。犁鼻器的损伤和初步的 2-脱氧葡萄糖数据表明 MP 可以由主嗅觉系统处理。然而，维持 MP 诱导的新生儿反应的神经元底物仍然未知。在这里，我们评估了暴露于 MP 的 4 日龄兔的嗅球和中枢脑区域水平的 Fos 表达（与暴露于不相关气味剂、无气味剂或未操作的幼仔的对照新生儿相比）。 MP 幼崽的主嗅球中出现了高且广泛的 Fos 免疫反应性，而副嗅球则表现出可忽略不计的染色。然而，当中性气味剂出现某种模式时，没有观察到明显的 Fos 表达的球状模式。与后者相比，MP暴露增加了前梨状皮层、终板血管器和缰核中Fos的表达，并且在外侧视前区有这种趋势。因此，第一次强调了对母婴互动至关重要的信息素，因为它由主要嗅觉系统、整个嗅球以及涉及渗透压调节、口渴和动机引导的运动反应的大脑区域进行处理。 (C) 2011 Elsevier B.V. 保留所有权利。
Chemosignals strongly contribute to social interactions in mammals, including mother-young relationships. In the European rabbit, a volatile compound emitted by lactating females in milk, the 2-methylbut-2-enal, has been isolated. Carrying the properties of a pheromone, in particular the spontaneous ability to release critical sucking-related movements in newborns, it has been called the mammary pheromone (MP). Lesion of the vomeronasal organ and preliminary 2-deoxyglucose data suggested that the MP could be processed by the main olfactory system. However, the neuronal substrate that sustains the MP-induced response of neonates remained unknown. Here, we evaluated Fos expression in 4-dayold-rabbits exposed to the MP (in comparison with control neonates exposed to non-relevant odorant, no odorant or unmanipulated pups) both at the level of the olfactory bulb and central brain regions. Evidence of high and widespread Fos immunoreactivity in the main olfactory bulb appear in MP pups while the accessory olfactory bulb exhibits a negligible staining. However, no obvious bulbar pattern of Fos expression is observed, when in contrast a certain pattern emerges with the neutral odorant. Compared to this latter, the MP exposure increases Fos expression in the anterior piriform cortex, the organum vasculosum of the lamina terminalis and the habenula, with a tendency in the lateral preoptic region. For the first time, a pheromone essential for mother-young interaction is thus highlighted for its processing by the main olfactory system, the whole olfactory bulb, and by brain regions involved in osmoregulation, thirst and motivation-guided motor responses. (C) 2011 Elsevier B.V. All rights reserved.