Relationship among adiponectin, adiponectin gene expression and fatty acids composition in morbidly obese patients
Relationship among adiponectin, adiponectin gene expression and fatty acids composition in morbidly obese patients
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DOI：
10.1007/s11695-007-9090-6
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发表时间：
2007-04-01
期刊：
影响因子：
2.9
通讯作者：
Garaulet, Marta
中科院分区：
文献类型：
--
作者：
Jose Hernandez-Morante, Juan;Ignacio Milagro, Fermin;Garaulet, Marta
背景资料：本研究的目的是探讨脂联素血浆循环水平和它的基因表达在两个腹部脂肪库（皮下和内脏）与血浆和脂肪组织中的脂肪酸组成在病态肥胖subjects.Methods：20例患者（10名女性和10名男性）之间的关系。所有患者均为病态肥胖（BMI >= 40 kg/m2），并入院接受胃手术。从皮下和内脏区域获得血浆样品和脂肪组织。结果：脂联素mRNA在皮下组织中的表达显著高于内脏组织（P=0.048）;循环脂联素值与血浆中n-3多不饱和脂肪酸的比例呈正相关（r=0.62，P=0.002）。内脏贮库显示脂联素基因表达和脂肪酸谱之间有更大的统计学关联，饱和脂肪酸与脂肪酸减少相关。（r=-0.68，P =0.015），而单不饱和脂肪酸与此脂肪区的增加有关结论：我们证实脂肪组织脂联素基因表达与脂肪酸组成之间存在显著相关性。这些关联在与内脏贮库相关时更为明显，内脏贮库是与代谢综合征高度相关的脂肪组织区域。
Background: The aim of this study was to examine the relationship between adiponectin plasma circulating levels and its gene expression in two abdominal fat depots (subcutaneous and visceral) with the fatty acid composition of plasma and adipose tissue in morbidly obese subjects.Methods: 20 patients (10 women and 10 men) were selected. All were morbidly obese (BMI >= 40 kg/m(2)) and admitted for gastric surgery. Plasma samples and adipose tissue from both subcutaneous and visceral regions were obtained. Plasma adiponectin and adipose adiponectin expression were analyzed.Results: Adiponectin mRNA expression in the subcutaneous tissue was significantly higher (P=0.048) than in visceral tissue. Circulating adiponectin values, were positively associated with the proportion of n-3 polyunsaturated fatty acids in plasma (r=0.62, P=0.002). The visceral depot showed greater statistical associations between adiponectin gene expression and fatty acids profile, being saturated fatty acids associated with a decrease (r=-0.68, P=0.015), whereas monounsaturated were related to an increase in this adipose region (r=0.67, P=0.017).Conclusions: We demonstrated significant associations between adipose tissue adiponectin gene expression and fatty acid composition. These associations were more evident in relation to the visceral depot, an adipose tissue region highly implicated in the metabolic syndrome.