Joint hypermobility syndrome is a risk factor trait for anxiety disorders: a 15-year follow-up cohort study
Joint hypermobility syndrome is a risk factor trait for anxiety disorders: a 15-year follow-up cohort study
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DOI：
10.1016/j.genhosppsych.2011.03.004
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发表时间：
2011-07-01
影响因子：
7
通讯作者：
Vilarroya, Oscar
中科院分区：
文献类型：
--
作者：
Bulbena, Antoni;Gago, Jordi;Vilarroya, Oscar
目的：这项研究的目的是评估是否关节过度活动综合征（JHS）是一个危险因素，发展焦虑症使用15年的前瞻性队列study.Method：最初的队列招募了158名受试者，年龄在16至20岁的一般人群在西班牙农村城镇。在基线和15年随访时对该队列进行了研究。使用Beighton标准评估关节过度活动综合征，使用精神疾病诊断和统计手册结构化临床访谈（第四版，疾病）评估精神疾病。基线时焦虑障碍的受试者被排除在follow-up.Results：在基线时关节过度活动综合征被发现在29 158例（21.1%）。随访时惊恐/广场恐怖症的累积发生率，作为主要诊断，JHS组（41.4%）显著高于对照组（1.9%），相对危险度为22.3 [95%置信区间（CI）4.6-108.7，P
Objective: The objective of the study was to assess whether joint hypermobility syndrome (JHS) is a risk factor for developing anxiety disorders using a 15-year prospective cohort study.Method: The initial cohort recruited 158 subjects aged 16 to 20 years from the general population in a Spanish rural town. The cohort was studied at baseline and at a 15-year follow-up. Joint hypermobility syndrome was assessed using Beighton's criteria, and the psychiatric disorders were assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Disorders. Subjects with anxiety disorders at baseline were excluded from the follow-up.Results: Joint hypermobility syndrome at baseline was found in 29 of 158 subjects (21.1%). Cumulative incidence of panic/agoraphobia disorder at follow-up, as main diagnosis, was significantly higher for the JHS group (41.4%) than for the control group (1.9%), with a relative risk of 22.3 [95% confidence interval (CI) 4.6-108.7, P