An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention.
An Overview of Carcinogenic Heavy Metal: Molecular Toxicity Mechanism and Prevention.
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DOI：
10.15430/jcp.2015.20.4.232
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发表时间：
2015-12
影响因子：
2.5
通讯作者：
Seo YR
中科院分区：
文献类型：
--
作者：
Kim HS;Kim YJ;Seo YR
几乎所有的重金属都是致癌的剧毒物质。然而，由于它们的化学和生理特性，重金属在工业领域包括合金、冶炼和商业产品的生产中是有用的。这些应用增加了重金属暴露的机会。工业过程产生的废物也是环境污染和人体积累的主要来源。砷、镉、铬和镍被国际癌症研究机构列为第1组致癌物，并在商业上使用。在这篇综述中，我们使用分子途径分析来了解这些金属的毒性和致癌机制。我们的分析数据表明，上述金属物质诱导氧化应激，DNA损伤和细胞死亡过程，导致癌症和癌症相关疾病的风险增加。因此，我们认为植物螯合素分子和抗氧化植物化学物质有助于预防重金属诱发的癌症。
Almost all heavy metals are serious toxicants as carcinogens. However, due to their chemical and physiological properties, heavy metals are useful in industrial areas including alloy, smelting and production of commercial products. Such applications increase the opportunity for heavy metal exposure. Waste from industrial processes is also a major source of environmental contamination and accumulation in the human body. Arsenic, cadmium, chromium, and nickel are classified as group 1 carcinogens by the International Agency for Research on Cancer, and are utilized commercially. In this review, we used molecular pathway analysis to understand the toxicity and carcinogenic mechanisms of these metals. Our analyzed data showed that above-mentioned metallic substances induce oxidative stress, DNA damage, and cell death processes, resulting in increase the risk of cancer and cancer-related diseases. Thus, we might think phytochelatin molecules and antioxidative phytochemical substances are helpful for prevention of heavy metal-induced cancer.