Regeneration of peripheral nerves after clenbuterol treatment in a rat model
Regeneration of peripheral nerves after clenbuterol treatment in a rat model
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大鼠模型中克伦特罗治疗后周围神经的再生
DOI：
10.1002/mus.10006
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发表时间：
2001
期刊：
影响因子：
3.4
通讯作者：
G. Keilhoff
中科院分区：
文献类型：
--
作者：
O. Frerichs;H. Fansa;P. Ziems;W. Schneider;G. Keilhoff
已知克仑特罗可作为中枢神经系统的神经保护物质，还可减少去神经后的肌肉萎缩。本研究的目的是评估其对周围神经再生的影响。大鼠坐骨神经模型分为四组（每组n = 8）。完成神经横断和显微手术接合后，两组每天口服 100 μg/kg 克仑特罗，两组作为对照组。 4周和6周后对再生进行临床、组织学和形态测量评估。计算小腿肌肉的重量比。组织学检查显示克伦特罗组的轴突数量显着增加，髓鞘形成程度也更好。 6周后，克伦特罗组的肌肉重量比显着增加，并且动物的后肢功能得到改善。因此，坐骨神经接合后每天使用 100 μg/kg 克伦特罗治疗对大鼠模型的临床、组织学和形态测量参数显示出积极影响。其根本机制仍不清楚。 © 2001 John Wiley & Sons, Inc. 肌肉神经 24：1687–1691，2001
Clenbuterol is known to act as a neuroprotective substance in the central nervous system, and also reduces muscle atrophy after denervation. The aim of this study was to evaluate its influence on peripheral nerve regeneration. The rat sciatic nerve model was used in four groups (n = 8 per group). After complete nerve transection and microsurgical coaptation, two groups received a daily oral dose of 100 μg/kg clenbuterol and two served as controls. Regeneration was assessed clinically, histologically, and morphometrically after 4 and 6 weeks. The weight ratios of calf muscles were calculated. Histological examination showed significantly increased axon counts in the clenbuterol group and a better degree of myelination. Muscle weight ratios of the clenbuterol group were significantly increased after 6 weeks, and the animals showed improved function of the hindlimb. Thus, therapy with 100 μg/kg clenbuterol daily after coaptation of a sciatic nerve showed a positive influence on clinical, histological, and morphometrical parameters in the rat model. The underlying mechanism remains unclear. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1687–1691, 2001