Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study
Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study
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DOI：
10.1194/jlr.p066423
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发表时间：
2016-07-01
影响因子：
6.5
通讯作者：
van Dam, Rob M.
中科院分区：
文献类型：
--
作者：
Sun, Ye;Koh, Hiromi W. L.;van Dam, Rob M.
我们的目的是在新加坡华人人群中研究血浆FAs、氧化脂素和急性心肌梗死（AMI）风险之间的前瞻性关联。在新加坡华人健康研究中，对744例AMI病例和744例47-83岁的匹配对照进行了巢式病例对照研究。采用质谱法对19种血浆FAs和12种氧脂质进行定量，采用分层聚类法将其分为12种FA簇和5种氧脂质簇，并评估其与AMI风险的相关性。长链n-3脂肪酸[比值比(OR) = 0.67 / SD增加，95%可信区间（CI）： 0.53-0.84, P < 0.001]和硬脂酸（OR = 0.65, 95% CI: 0.44-0.97, P = 0.03）与AMI风险呈负相关，而花生四烯酸（AA）与AMI风险呈正相关（OR = 1.25, 95% CI: 1.03-1.52, P = 0.02）。进一步调整氧化脂素并没有实质性地改变这些关联。aa衍生的氧脂素、血栓素（TX） B-2与AMI风险呈负相关（OR = 0.81, 95% CI: 0.71-0.93, P = 0.003）。在中国人群中，循环长链n-3脂肪酸和硬脂酸与较低的AMI风险相关，AA与较高的AMI风险相关。氧化脂素TXB2与AMI之间的关系有待进一步研究。-孙，Y, Hiromi W. L. Koh， H. Choi， W. p。Koh J-M。袁，纽曼，苏，方俊，王志宁，范丹。血浆脂肪酸、氧化脂素与心肌梗死风险：新加坡华人健康研究
We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47-83 years was conducted within the Singapore Chinese Health Study. Nineteen plasma FAs and 12 oxylipins were quantified using MS. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed. Long-chain n-3 FAs [odds ratio (OR) = 0.67 per SD increase, 95% confidence interval (CI): 0.53-0.84, P < 0.001] and stearic acid (OR = 0.65, 95% CI: 0.44-0.97, P = 0.03) were inversely associated with AMI risk, whereas arachidonic acid (AA) was positively associated with AMI risk (OR = 1.25, 95% CI: 1.03-1.52, P = 0.02) in the multivariable model with adjustment for other FAs. Further adjustment for oxylipins did not substantially change these associations. An inverse association was observed between AA-derived oxylipin, thromboxane (TX) B-2, and AMI risk (OR = 0.81, 95% CI: 0.71-0.93, P = 0.003). Circulating long-chain n-3 FAs and stearic acid were associated with a lower and AA was associated with a higher AMI risk in this Chinese population. The association between the oxylipin TXB2 and AMI requires further research.-Sun, Y., Hiromi W. L. Koh, H. Choi, W-P. Koh, J-M. Yuan, J. W. Newman, J. Su, J. Fang, C. N. Ong, and R. M. van Dam. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study.