Living with epilepsy in Lubumbashi (Democratic Republic of Congo): epidemiology, risk factors and treatment gap.
Living with epilepsy in Lubumbashi (Democratic Republic of Congo): epidemiology, risk factors and treatment gap.
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卢本巴希（刚果民主共和国）的癫痫患者：流行病学、危险因素和治疗差距。
DOI：
10.11604/pamj.2015.21.303.5580
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mesu'aKabwa,PierreLuabeya
中科院分区：
文献类型：
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作者：
KobaBora,Béatrice;Lez,DidierMalamba;Luwa,DanielOkitundu;Baguma,MarcellinBugeme;Katumbay,DésiréTshala;Kalula,TharcisseKayembe;Mesu'aKabwa,PierreLuabeya
导言：癫痫是最常见的严重神经疾病，然而，尽管作出了相当大的努力，但很难获得良好的药物治疗、适当的社会和社会接受以及可接受的生活质量，特别是在发展中国家。据估计，刚果民主共和国有50多万人患有癫痫。方法：对卢本巴希CNPJG门诊12个月内确诊为癫痫的患者进行描述性研究。采用项目问卷对患者进行问卷调查。结果：在Fracarita慈善机构开办的一家神经精神科诊所1年的时间里，3540名患者中有423人(11.9%)被确认为癫痫，179人在他们(或他们的父母/监护人)知情同意并完成脑电调查后被纳入调查。数据是使用标准化的项目问卷收集的。癫痫对患有癫痫的人的生活有负面影响；40.8%的人没有受过教育或只完成了初等教育，38.0%的人失业，大多数(64.6%；n=113)未婚或离婚。23.5%的病例有癫痫家族史(1级或2级)。其他可能诱发癫痫的潜在因素包括产科和围产期因素(15.1%)和婴儿期中枢神经系统感染(8.4%)。饮酒或娱乐用药占10.6%。治疗间隔在67%以上，首次发作至首次就诊的间隔时间为15个月。当被要求描述他们的病情或其原因时，55.3%的参与者(或他们的家人)认为癫痫是由精神/宗教原因引起的，而25.1%的参与者几乎没有洞察力，无法提供任何描述。结论：这项首次流行病学研究显示，在刚果民主共和国卢本巴希的诊所就诊的患者中癫痫的发病率很高，并揭示了显著的治疗差距。
Introduction: Epilepsy is the most common of serious neurological disorders, yet despite considerable efforts, good access to medication, appropriate social and societal acceptance and acceptable quality of life (QoL) are difficult to achieve especially in developing countries. It is estimated that over 500,000 people suffer from epilepsy in the DRC. There is no report, in our knowledge on the epilepsy in ubumbashi.Methods: A descriptive study was undertaken in individuals with a clinical diagnosis of epilepsy who presented at the CNPJG outpatient clinic in Lubumbashi over a 12 months period. A 64-item questionnaire was used to collect information from the patients. Case records were reviewed and relevant demographic, social, professional, medical history, medical condition data were extracted.Results: Among 3,540 patients who presented to a neuropsychiatric clinic run by the Fracarita charity over a 1-year period, 423 (11.9%) were identified as having epilepsy, and 179 were subsequently included in the survey after they (or their parent/guardian) provided informed consent and completed an EEG investigation. Data were collected using a standardized, 64-item questionnaire. Epilepsy had negative impact on the lives of individuals with the condition; 40.8% had either no education or had completed primary education only, 38.0% were unemployed and the majority (64.6%; n= 113) were unmarried or divorced. Family history of epilepsy (first or second degree) was present in 23.5% of cases. Other reported factors that could potentially precipitate epilepsy included obstetric and perinatal factors (15.1%) and central nervous system infections during infancy (8.4%). Consumption of alcohol or recreational drugs accounted for 10.6%. The treatment gap was above 67% and the delay between first seizure and first consultation was 15 months. When asked to describe their condition, or its cause, 55.3% of participants (or their families) considered epilepsy to be of spiritual/religious origin, while 25.1% had almost no insight and could not provide any description.Conclusion: This first epidemiological study shows a high prevalence of epilepsy among patients presenting to the clinic in Lubumbashi, DRC, and reveals a significant treatment gap.