Novel amphiphilic cyclic oligosaccharides: Synthesis and self-aggregation properties
Novel amphiphilic cyclic oligosaccharides: Synthesis and self-aggregation properties
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DOI：
10.1021/jo7017087
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发表时间：
2007-12-07
影响因子：
3.6
通讯作者：
Montesarchio, Daniela
中科院分区：
文献类型：
--
作者：
Coppola, Cinzia;Saggiomo, Vittorio;Montesarchio, Daniela
新型两亲性环状二糖类似物，其中糖单元通过稳定的磷酸二酯键（CyPLOS，环状磷酸连接寡糖）连接，并在2-和3-OH部分用长的亲脂性触手装饰，已经合成。他们的倾向，自聚集已被调查的H-1和P-31 NMR实验的装置，使之有可能确定这些大环的临界聚集浓度值，毫摩尔范围内。
[GRAPHICS]Novel amphiphilic cyclic disaccharide analogues, in which the saccharide units are connected through stable phosphodiester linkages (CyPLOS, Cyclic Phosphate-Linked OligoSaccharides) and decorated with long lipophilic tentacles at the 2- and 3-OH moieties, have been synthesized. Their propensity to self-aggregation has been investigated by means of H-1 and P-31 NMR experiments, making it possible to determine for these macrocycles critical aggregation concentration values in the,millimolar range.