Microstructural Damage in Normal-Appearing Brain Parenchyma and Neurocognitive Dysfunction in Adult Moyamoya Disease
Microstructural Damage in Normal-Appearing Brain Parenchyma and Neurocognitive Dysfunction in Adult Moyamoya Disease
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DOI：
10.1161/strokeaha.118.022367
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发表时间：
2018-10-01
期刊：
影响因子：
8.3
通讯作者：
Nariai, Tadashi
中科院分区：
文献类型：
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作者：
Hara, Shoko;Hori, Masaaki;Nariai, Tadashi
背景和目的。慢性脑缺血引起的脑微结构损伤在成人烟雾病（MMD）的神经认知功能障碍中起着关键作用。我们使用称为神经突方向弥散和密度成像的多壳层弥散磁共振成像技术研究了MMD患者脑微结构的特定变化及其与神经认知功能障碍的相关性。（16-63岁，20名女性）和20名年龄和性别匹配的正常志愿者，使用神经突方向分散和密度成像和神经心理电池。神经突取向分散和密度成像计算2个参数：细胞内体积分数（维克），其反映白色物质中的轴突密度和皮质中的树突密度;以及取向分散指数（OD），其反映网络复杂性。结果MMD患者白色物质的维克比正常对照组明显降低（P < 0.05），主要是皮质的OD比正常对照组明显降低（P < 0.05），而皮质的OD比正常对照组明显降低（P < 0.05）。
Background and Purpose. Microstructural damage in the brain induced by chronic ischemia is suggested to play a pivotal role in the neurocognitive dysfunction of adults with Moyamoya disease (MMD). We investigated specific changes in the brain microstructure and their correlations with neurocognitive dysfunction in patients with MMD using a multishell diffusion magnetic resonance imaging technique called neurite orientation dispersion and density imaging.Methods-We evaluated 26 patients with MMD (16-63 years old, 20 females) and 20 age-and sex-matched normal volunteers using neurite orientation dispersion and density imaging and neuropsychological batteries. Neurite orientation dispersion and density imaging calculates 2 parameters: the intracellular volume fraction (Vic), which reflects the axon density in the white matter and dendrite density in the cortex, and the orientation dispersion index (OD), which reflects the network complexity. The microstructural damage and its correlation with neurocognitive performance were evaluated by performing a whole-brain analysis using SPM12 and correlation analysis with regional values.Results-Patients with MMD had significantly lower Vic in the white matter and a lower OD mainly in the cortex than those of the controls (P