Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses
Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses
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DOI：
10.1016/j.micinf.2020.01.004
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发表时间：
2020-03-01
影响因子：
5.8
通讯作者：
Chen, Jieliang
中科院分区：
文献类型：
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作者：
Chen, Jieliang
一种人畜共患冠状病毒，被世界卫生组织（WHO）暂时标记为2019-nCoV，已被确定为2019年底中国武汉病毒性肺炎疫情的病原体。虽然2019-nCoV可以引起严重的呼吸道疾病，如SARS和MERS，但临床证据表明，2019-nCoV的致病性通常低于SARS-CoV，远低于MERS-CoV。2019-nCoV的可传播性仍有争议，需要进一步评估。为了避免2019-nCoV疫情演变为流行病甚至大流行，并将死亡率降至最低，中国启动了应急响应程序，但仍需了解该病毒的特征，以完善风险评估和应对措施。在这里，总结了2019-nCoV致病性和传播性的现有知识，并与几种常见的新出现的病毒进行了比较，并强调了更好地控制该疾病所迫切需要的信息。(C)2020作者（S）由Elsevier Masson SAS代表巴斯德研究所发布。
A zoonotic coronavirus, tentatively labeled as 2019-nCoV by the World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. The transmissibility of 2019-nCoV is still debated and needs to be further assessed. To avoid the 2019-nCoV outbreak turning into an epidemic or even a pandemic and to minimize the mortality rate, China activated emergency response procedures, but much remains to be learned about the features of the virus to refine the risk assessment and response. Here, the current knowledge in 2019-nCoV pathogenicity and transmissibility is summarized in comparison with several commonly known emerging viruses, and information urgently needed for a better control of the disease is highlighted. (C) 2020 The Author(s). Published by Elsevier Masson SAS on behalf of Institut Pasteur.