Cyclodextrin conjugated magnetic colloidal nanoparticles as a nanocarrier for targeted anticancer drug delivery
Cyclodextrin conjugated magnetic colloidal nanoparticles as a nanocarrier for targeted anticancer drug delivery
复制标题
DOI：
10.1088/0957-4484/19/26/265602
复制
发表时间：
2008-07-02
期刊：
影响因子：
3.5
通讯作者：
Chen, Dong-Hwang
中科院分区：
文献类型：
--
作者：
Banerjee, Shashwat S.;Chen, Dong-Hwang
以六亚甲基二异氰酸酯(HMDI)为连接剂，将环糊精(CD)接枝到阿拉伯树胶修饰的磁性纳米颗粒(GAMNPs)上，制备了一种新型磁性纳米载体(CD-GAMNPs)，用于靶向给药。透射电子显微镜和动态光散射分析表明，产物的平均直径为17.1 nm，流体力学平均直径为44.1 nm。傅里叶变换红外光谱(FTIR)和热重分析(TGA)表明GAMNPs表面接枝了Cd，接枝量为16.8mgg-1。抗癌药物全反式维甲酸(RA)的负载研究表明，由于Cd的特殊疏水空腔结构，新制备的磁性纳米载体与GAMNPs相比具有相当高的吸附能力，可以作为主客体与维甲酸的络合物。此外，还发现CD-GAMNPs与维甲酸的络合是放热的，表面活性剂(十二烷基硫酸钠)的存在导致了维甲酸包结物的减少，这是因为十二烷基硫酸钠的线形结构使其更容易进入CD的空腔。此外，维甲酸在CD-GAMNPs中的体外释放曲线表现为先快速释放后延迟释放的特征。
A novel magnetic nanocarrier (CD-GAMNPs) was fabricated for targeted anticancer drug delivery by grafting cyclodextrin ( CD) onto gum arabic modified magnetic nanoparticles (GAMNPs) using hexamethylene diisocyanate ( HMDI) as a linker. Analyses by transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 17.1 nm and a mean hydrodynamic diameter of 44.1 nm. The CD grafting was confirmed by Fourier transform infrared ( FTIR) spectroscopy, and thermogravimetric analysis (TGA) indicated that the amount of CD grafted on the GAMNPs was 16.8 mg g(-1). The study on the loading of anticancer drug all-trans-retinoic acid ( retinoic acid) revealed that the newly fabricated magnetic nanocarrier possessed a considerably higher adsorption capability as compared to GAMNPs due to the special hydrophobic cavity structure of CD, which could act as a host-guest complex with retinoic acid. Furthermore, it was found that the complexation of CD-GAMNPs with retinoic acid was exothermic and the presence of a surfactant ( sodium dodecyl sulfate) led to the decrease in the inclusion of retinoic acid because the linear structure of sodium dodecyl sulfate made it easier to enter the cavity of CD as compared to less linear retinoic acid. In addition, the in vitro release profile of retinoic acid from CD-GAMNPs was characterized by an initial fast release followed by a delayed release phase.