Alkali production by oral bacteria and protection against dental caries.
Alkali production by oral bacteria and protection against dental caries.
复制标题
DOI：
10.1111/j.1574-6968.2000.tb09393.x
复制
发表时间：
2000-12
影响因子：
2.1
通讯作者：
R. Burne;R. E. Marquis
中科院分区：
文献类型：
--
作者：
R. Burne;R. E. Marquis
pH是影响口腔生物膜的生理、生态和致病性的关键环境因素。口腔致病菌通过代谢碳水化合物产生有机酸的研究已引起人们的广泛关注。现在，有证据表明，碱的产生，特别是通过精氨酸和尿素的氨的生产，在口腔生物膜的pH稳态中起着重要作用，并可能缓和龋齿的发生和发展。这篇简短的综述强调了最近的进展，了解分子遗传和生理方面的氨产生的突出口腔细菌。
pH is a key environmental factor affecting the physiology, ecology and pathogenicity of the oral biofilms colonizing the hard tissues of the human mouth. Much attention has been focused on the production of organic acids through the metabolism of carbohydrates by pathogenic oral bacteria. Now, evidence is emerging that alkali generation, particularly through ammonia production from arginine and urea, plays major roles in pH homeostasis in oral biofilms and may moderate initiation and progression of dental caries. This short review highlights recent progress on understanding molecular genetic and physiologic aspects of ammonia generation by prominent oral bacteria.