Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864
Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864
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DOI：
10.1111/bph.13099
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发表时间：
2015-06
影响因子：
7.3
通讯作者：
Yiming Wang;Yiming Wang;T. Kunit;A. Ciotkowska;B. Rutz;Andrea Schreiber;Frank Strittmatter;R. Waidelich;Chunxiao Liu;Christian G Stief;C. Gratzke;M. Hennenberg
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文献类型：
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作者：
Yiming Wang;Yiming Wang;T. Kunit;A. Ciotkowska;B. Rutz;Andrea Schreiber;Frank Strittmatter;R. Waidelich;Chunxiao Liu;Christian G Stief;C. Gratzke;M. Hennenberg
提示良性前列腺增生 (BPH) 的下尿路症状 (LUTS) 的药物治疗目标是前列腺平滑肌收缩或前列腺生长。然而，目前的治疗选择还不够。在这里，我们研究了 Rac 在控制人类前列腺平滑肌张力和前列腺基质细胞生长中的作用。
Medical therapy of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) targets smooth muscle contraction in the prostate, or prostate growth. However, current therapeutic options are insufficient. Here, we investigated the role of Rac in the control of smooth muscle tone in human prostates and growth of prostate stromal cells.