Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.
Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.
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DOI：
10.1097/qad.0000000000001854
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发表时间：
2018-07-17
期刊：
影响因子：
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通讯作者：
Hoare J
中科院分区：
文献类型：
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作者：
Horvath S;Stein DJ;Phillips N;Heany SJ;Kobor MS;Lin DTS;Myer L;Zar HJ;Levine AJ;Hoare J
最近的研究表明，人类免疫缺陷病毒-1（HIV）感染与成年人的加速衰老效应有关，这是根据一种高度准确的衰老表观遗传生物标志物（称为表观遗传时钟）进行的。然而，目前尚不清楚表观遗传年龄加速是否早在青春期发生在围产期艾滋病毒感染（PHIV+）的青年。对参加开普敦青少年抗逆转录病毒队列（CTAAC）研究的PHIV和HIV未感染青少年的观察性研究。Illumina EPIC阵列用于生成204名PHIV和44名年龄匹配的9至12岁未感染（HIV-）青少年的血液DNA甲基化数据。表观遗传时钟软件和方法被用来估计表观遗传年龄加速的两个措施。每位参与者在加入CTAAC后完成了全面的神经心理学测试。根据表观遗传年龄加速的两种措施，HIV与PHIV+青少年的生物学年龄较大的血液相关。其中一项措施，外在表观遗传年龄加速，与认知功能（执行功能，工作记忆，处理速度）的措施呈负相关。总的来说，我们的研究结果表明，血液中的表观遗传年龄加速可以在PHIV+青少年中观察到，这些表观遗传变化伴随着较差的认知功能。
Recent studies demonstrate that infection with the Human Immunodeficiency Virus-1 (HIV) is associated with accelerated aging effects in adults according to a highly accurate epigenetic biomarker of aging known as epigenetic clock. However, it not yet known whether epigenetic age acceleration occurs as early as adolescence in perinatally HIV-infected (PHIV+) youth. Observational study of PHIV and HIV-uninfected adolescents enrolled in the Cape Town Adolescent Antiretroviral Cohort (CTAAC) Study. The Illumina EPIC array was used to generate blood DNA methylation data from 204 PHIV and 44 age-matched, uninfected (HIV-) adolescents aged 9 to 12 years old. The epigenetic clock software and method was used to estimate two measures of epigenetic age acceleration. Each participant completed a comprehensive neuropsychological test battery upon enrolment to CTAAC. HIV is associated with biologically older blood in PHIV+ adolescents according to both measures of epigenetic age acceleration. One of the measures, extrinsic epigenetic age acceleration, is negatively correlated with measures of cognitive functioning (executive functioning, working memory, processing speed). Overall, our results indicate that epigenetic age acceleration in blood can be observed in PHIV+ adolescents and that these epigenetic changes accompany poorer cognitive functioning.