THE ROLE OF HEMOGLOBIN DENATURATION AND BAND-3 CLUSTERING IN RED BLOOD-CELL AGING
THE ROLE OF HEMOGLOBIN DENATURATION AND BAND-3 CLUSTERING IN RED BLOOD-CELL AGING
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DOI：
10.1126/science.2578228
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
DRENCKHAHN, D
中科院分区：
文献类型：
--
作者：
LOW, PS;WAUGH, SM;DRENCKHAHN, D
当血红蛋白开始变性时，它形成半染色质，将主要的红细胞跨膜蛋白带3交联成簇。这些簇提供针对衰老细胞的抗体的识别位点。这些抗体与老化的红细胞结合，并触发其从循环中清除。[研究了人类红细胞]。
As Hb begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation. [Human red blood cells were studied.].