A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission

A self-delivery DNA nanoprobe for reliable microRNA imaging in live cells by aggregation induced red-shift-emission
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一种自传递 DNA 纳米探针,通过聚集诱导红移发射在活细胞中进行可靠的 microRNA 成像

DOI:
10.1039/c9cc08093g
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发表时间:
2020-02-04
影响因子:
4.9
通讯作者:
Tian, Leilei
Tian, Leilei
中科院分区:
化学2区
文献类型:
--
作者:
Chen, Zhe;Lu, Jingxiong;Tian, Leilei

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A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer-monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.