Outstanding issues surrounding vomeronasal mechanisms of pregnancy block and individual recognition in mice
Outstanding issues surrounding vomeronasal mechanisms of pregnancy block and individual recognition in mice
复制标题
DOI：
10.1016/j.bbr.2008.10.045
复制
发表时间：
2009-06-25
影响因子：
2.7
通讯作者：
Brennan, Peter A.
中科院分区：
文献类型：
--
作者：
Brennan, Peter A.
雄性小鼠的尿液中含有复杂的化学信号混合物，这些化学信号是生殖活跃的雄性存在的信号。这些信息素对雌性生殖状态有强大的影响，包括阻止怀孕的能力。雄鼠的尿液也含有个性化学信号，使雌鼠能够识别她的配偶，并防止他的信息素引发怀孕阻滞效应。一系列的神经化学和电生理证据表明，记忆的形成交配男性的信息素涉及突触的变化，在第一阶段的犁鼻途径的副嗅球。这导致选择性地抑制配偶的信息素信号，阻止它激活皮质杏仁核和下丘脑中的神经回路，这些神经回路介导导致妊娠阻滞的内分泌变化。本文回顾了目前的知识状态，这种配偶识别的神经生物学基础，突出了我们目前的理解的重要差距。尽管最近的研究发现与主要组织相容性复合体相关的肽能够影响配偶识别，但妊娠阻断和个性化学信号仍有待确定。最近的研究也使我们对去甲肾上腺素印记雄性信息素信号的机制的理解产生了怀疑。最后，学习对犁鼻系统信息传递的影响及其与主要嗅觉系统处理的化学感觉信息的关系仍有待阐明。(C)2008 Elsevier B.V.保留所有权利。
Male mouse urine contains a complex mixture of chemosignals, which signal the presence of a reproductively active male. These have powerful effects as primer pheromones on female reproductive state, including the ability to block pregnancy. Male mouse urine also contains individuality chemosignals that enable the female to recognise her mate and prevent his pheromones from eliciting the pregnancy block effect. A range of neurochemical and electrophysiological evidence suggests that memory formation to the mating male's pheromones involves synaptic changes in the accessory olfactory bulb, at the first stage of the vomeronasal pathway. This results in a selective inhibition of the mate's pheromonal signal, preventing it from activating neural circuits in the corticomedial amygdala and hypothalamus that mediate the endocrine changes responsible for pregnancy block. This article reviews the current state of knowledge regarding the neurobiological basis of this mate recognition, highlighting important gaps in our current understanding. Despite recent findings of the ability of peptides associated with the major histocompatibility complex to influence mate recognition, the pregnancy blocking and individuality chemosignals remain to be identified. Recent research has also shed doubt on our understanding of the mechanism by which noradrenaline imprints the male pheromonal signal. Finally, the effect of learning on the transmission of information in the vomeronasal system and its relationship to chemosensory information processed by the main olfactory system remain to be elucidated. (C) 2008 Elsevier B.V. All rights reserved.