Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas
Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas
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用于胶质母细胞瘤靶向成像的氯毒素衍生双环肽
DOI：
10.1039/d0cc01089h
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发表时间：
2020
影响因子：
4.9
通讯作者：
Fang Lijing
中科院分区：
文献类型：
--
作者：
Li Meiqing;Shao Ximing;Wu Chunlei;Lu Danyi;Liu Ke;Wang Wei;Liu Jiakai;Li Hongchang;Su Wu;Fang Lijing
利用设计的四功能化学连接剂环化完全无保护的线性肽，为获得氯毒素衍生的双环肽-生物分子偶联物提供了一种方便、高效的策略。在这些多肽中，含有氯毒素n端序列的bicycle-P3具有较高的肿瘤选择性和穿透能力，有望用于胶质瘤的治疗。
A convenient and efficient strategy was developed for accessing chlorotoxin-derived bicyclic peptide-biomolecule conjugates by cyclizing fully-unprotected linear peptides with a designed tetrafunctional chemical linker. Among these peptides, bicycle-P3 bearing the N-terminal sequence of chlorotoxin shows high tumor selectivity and penetration ability, which is promising for treatment of gliomas.