The relationship between sleep and opioids in chronic pain patients.
The relationship between sleep and opioids in chronic pain patients.
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慢性疼痛患者睡眠与阿片类药物的关系。
DOI：
10.1007/s10865-021-00205-1
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发表时间：
2021-06
影响因子：
3.1
通讯作者：
Wachholtz A
中科院分区：
文献类型：
--
作者：
Frers A;Shaffer J;Edinger J;Wachholtz A
睡眠问题在服用阿片类药物的慢性疼痛患者中很常见。阿片类药物对睡眠结构的影响已有记录;然而，阿片类药物对睡眠的长期影响仍然未知。这项研究检查了阿片类药物初治参与者的睡眠质量是否比目前和以前的阿片类药物长期使用者更好。我们还探讨了美沙酮和丁丙诺啡使用者之间的睡眠是否不同，以及戒断阿片类药物后的时间是否与睡眠质量相关。参与者为120名慢性疼痛患者（84.2%为白人，法师= 42.0岁，SD = 11.44）。他们分为四组，每组30名参与者：1）目前使用美沙酮治疗阿片类药物使用障碍（OUD）; 2）目前使用丁丙诺啡治疗OUD; 3）有药物辅助治疗OUD的历史，但目前阿片类药物戒断至少6个月; 4）累积终身阿片类药物不足一个月的人（阿片类药物初治组）。只有第1组和第2组的参与者在研究期间服用阿片类药物。参与者完成了匹兹堡睡眠质量指数和SF-36。MANCOVA显示，目前或以前使用阿片类药物的所有三个组（即，第1-3组）在睡眠质量、睡眠持续时间、睡眠障碍和控制睡眠药物后的日间功能障碍方面与阿片类药物初治组（第4组）有显著差异（所有P <0.05）。对于第1组（美沙酮使用者）、第2组（丁丙诺啡使用者）和第3组（长期戒断），各组之间没有统计学显著差异。阿片类药物戒断周数与阿片类药物戒断组的睡眠障碍之间也存在显著关系（r =-0.604，p < .001）。这项研究的结果表明，阿片类药物干扰睡眠质量，即使在几个月的预防之后。对阿片类药物的长期影响的进一步研究是必要的，可能会进一步有助于解决这一人群的睡眠问题的重要性。
Sleep problems are common among chronic pain patients who take opioids. There are documented effects of opioids on sleep architecture; however, the long-term effects of opioids on sleep remain unknown. This study examined whether opioid-naïve participants have better sleep quality than current and previous chronic users of opioids. We also explored whether sleep differed between methadone and buprenorphine users, and whether amount of time since abstaining from opioids was associated with sleep quality. Participants were 120 people with chronic pain (84.2% Caucasian, Mage = 42.0 years, SD = 11.44). They were in one of four groups of 30 participants each: 1) current users of methadone for opioid use disorder (OUD); 2) current users of buprenorphine for OUD; 3) a history of medication-assisted therapy for OUD but currently opioid-abstinent for at least 6 months; 4) those who have less than one month of cumulative lifetime opioids (opioid-naïve group). Only participants in group 1 and group 2 were taking opioids during the time of the study. Participants completed the Pittsburgh Sleep Quality Index and the SF-36. A MANCOVA revealed that all three groups with current or previous opioid use (i.e., groups 1-3) differed significantly from the opioid-naïve group (group 4) on sleep quality, sleep duration, sleep disturbances, and daytime dysfunction after controlling for sleep medications (all p < .05). For group 1 (methadone users), 2 (buprenorphine users), and 3 (prolonged abstinence), there were no statistically significant differences between each group. There was also a significant relationship between opioid-abstinent weeks and sleep disturbances in the opioid-abstinent group (r = −0.604, p < .001). The results of this study suggest that opioids interfere with sleep quality, even after months of abstention. Further research into the long-term effects of opioids is warranted and may contribute further to the importance of addressing sleep problems in this population.
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影响因子：
3.9
作者：
Fei, Joni Teoh Bing;Yee, Anne;Danaee, Mahmoud
通讯作者：
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
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影响因子：
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Czerwinski, S. A.
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Hohagen, F