Concomitant stromal tumor and early cancer of the stomach: What should be done?
Concomitant stromal tumor and early cancer of the stomach: What should be done?
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并发间质瘤和早期胃癌：应该做什么？
DOI：
10.1097/md.0000000000007576
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发表时间：
2017
期刊：
影响因子：
1.6
通讯作者：
Ouyang,Miao
中科院分区：
文献类型：
--
作者：
Xu,Yan;Shen,Liangfang;Lu,Zhaoxia;Liu,Xiaowei;Wu,Wei;Feng,Deyun;Rao,JaladankiN;Xiao,Lan;Ouyang,Miao
合并胃间质瘤（GST）和胃癌（GC）并不常见;更少见的是合并GST和早期GC（EGC）。尚未报告通过内镜粘膜下剥离术（ESD）切除肿瘤以治疗GST和EGC合并症。我们试图确定在第一次食管胃内窥镜检查（EGD）中检测合并GST和EGC的临床重要性，并比较ESD与根治性手术治疗合并GST和EGC的临床结局。我们的研究是一项回顾性队列研究。2005年1月至2015年1月，在大学附属医院招募了接受ESD或根治性手术的合并GST和EGC患者。首次EGD时GST和EGC的检出率为3/25（12%）。25例患者中，14例接受ESD，11例接受手术。ESD组的平均手术时间和住院时间明显短于手术组。在整块切除、完全切除和早期并发症的发生率方面没有显著差异。手术组的晚期并发症比ESD组更常见。中位随访时间为58.9个月。两组的3年或5年总生存率均为100%，无患者死于EGC和GST。两组均无局部复发，但ESD组在随访期间发现3个异时EGC病灶：GST和EGC同时发生的情况不常见，首次EGD时GST和EGC的检出率很低; ESD似乎是一种安全、有效和受欢迎的GST和EGC合并治疗选择，符合ESD的绝对适应症，结果与手术结果相当。
Concomitant gastric stromal tumor (GST) and gastric cancer (GC) is uncommon; even more uncommon is a concomitant GST and early stage GC (EGC). Tumor resection by endoscopic submucosal dissection (ESD) for concomitant GST and EGC has not been reported. We sought to define the clinical importance of detection of concomitant GST and EGC during the first esophagogastroduodenoscopy (EGD), and compare the clinical outcomes of ESD versus radical surgery for the treatment of concomitant GST and EGC. Our investigation was a retrospective cohort study. Patients with concomitant GST and EGC who underwent ESD or radical surgery were enrolled at the university-affiliated hospital from January 2005 to January 2015. The detection rate of concomitant GST and EGC during the first EGD was 3/25 (12%). Among 25 patients, 14 underwent ESD and 11 underwent surgery. Mean operation time and hospital stay were significantly shorter in the ESD group than the surgery group. There were no significant differences in terms of rates of en bloc resection, complete resection, and early complications. Late complications were more common in the surgery group than in the ESD group. The median follow-up duration was 58.9 months. Three-or 5-year overall survival rates were 100% for both groups and no patient died of EGC and GST. There was no local recurrence in the 2 groups; however, 3 metachronous EGC lesions were found during the follow-up period in the ESD group as follows: the simultaneous occurrence of GST and EGC was uncommon; the detection rate of concomitant GST and EGC was very low at the first EGD; and ESD appeared to be a safe, efficient, and popular treatment option for concomitant GST and EGC, that met the ESD absolute indication, and the outcomes were comparable to those achieved with surgery.
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影响因子：
6.1
作者：
J. Priestle
通讯作者：
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影响因子：
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作者：
B. C. Wang
通讯作者：
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DOI：
10.1073/pnas.88.7.2773
发表时间：
1991-04-01
影响因子：
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作者：
KURIYAN, J;WEIS, WI
通讯作者：
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DOI：
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发表时间：
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期刊：
Journal of Ultrastructure Research
影响因子：
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作者：
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影响因子：
3.8
作者：
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通讯作者：
C. Garner