The Relationship Between HIV Infection and Cardiovascular Disease.
The Relationship Between HIV Infection and Cardiovascular Disease.
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DOI：
10.2174/157340308785160589
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发表时间：
2008-08
影响因子：
1.9
通讯作者：
Holodniy M
中科院分区：
文献类型：
--
作者：
Dau B;Holodniy M
目前有3 000多万人感染人体免疫缺陷病毒（艾滋病毒），每年有200多万人新感染。已发现HIV直接影响血管生物学，导致与未感染者相比心血管疾病的风险增加。虽然艾滋病毒感染现在可以有效地治疗联合抗逆转录病毒药物，严重的毒性，如高脂血症，糖尿病和过多的心血管并发症，以及艾滋病毒和心血管药物之间的潜在显着药物相互作用，提出了新的挑战，艾滋病毒感染者的管理。我们首先回顾艾滋病毒的发病机制和治疗的基本原则，然后讨论相关的临床管理策略，这将是有用的心脏病专家谁可能参与艾滋病毒感染者的护理。
Over 30 million people are currently living with human immunodeficiency virus (HIV) infection, and over 2 million new infections occur per year. HIV has been found to directly affect vascular biology resulting in an increased risk of cardiovascular disease compared to uninfected persons. Although HIV infection can now be treated effectively with combination antiretroviral medications, significant toxicities such as hyperlipidemia, diabetes, and excess cardiovascular co-morbidity; as well as the potential for significant drug-drug interactions between HIV and cardiovascular medications, present new challenges for the management of persons infected with HIV. We first review basic principles of HIV pathogenesis and treatment and then discuss relevant clinical management strategies that will be useful for cardiologists who might be involved in the care of HIV infected patients.