Incidence and survival of neuroendocrine tumours in the Netherlands according to histological grade: Experience of two decades of cancer registry
Incidence and survival of neuroendocrine tumours in the Netherlands according to histological grade: Experience of two decades of cancer registry
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DOI：
10.1016/j.ejca.2012.12.022
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发表时间：
2013-05-01
影响因子：
8.4
通讯作者：
Visser, Otto
中科院分区：
文献类型：
--
作者：
Korse, Catharina M.;Taal, Babs G.;Visser, Otto
目的：神经内分泌肿瘤(NETs)的流行病学研究普遍显示其发病率有较大的增加。方法：根据世界卫生组织(WHO)最新的消化系统分类，对所有47,800例Net(确诊为1990-2010年)患者进行分层：高分化Net 1级和2级(G1NET和G2NET)和低分化(3级)神经内分泌癌，细分为大细胞(G3-LCNEC)和小细胞(G3-SCNEC)。结果：年龄标化发病率(不包括G3-SCNEC)从1990年的2.1/10万上升到2010年的4.9/10万。G1NET的发病率从2.0上升到3.0；G2NET从1990年的0.01上升到2010年的0.2，G3-LCNEC从0.01上升到1.8。在G3-SCNEC中，男性的发病率从21.3下降到10.1，而女性的发病率从4.5上升到7.7。G1NET组5年生存率由1990-2000年的30%提高到2001-2010年的47%。结论：Net(无G3-SCNEC)的发生率增加主要是由于G3-LCNEC的增加。这一增长与诊断程序的改进以及病理从其他实体(如未分化癌)转移到净额有关。所有部位和分期的生存率都有所提高，特别是在转移性G1NET患者中。由于其对发病率和存活率的影响，我们建议根据组织学分类在NET上进行流行病学研究。(C)爱思唯尔有限公司出版的2013年。
Purpose: Epidemiological studies on neuroendocrine tumours (NETs) generally show a major increase in incidence. To investigate this increase, epidemiological data from the Netherlands were evaluated according to histological grade.Methods: All 47,800 patients with NET (diagnosed 1990-2010) from the population-based Netherlands Cancer Registry were stratified according to the latest World Health Organization (WHO) classification for the digestive system: well-differentiated NET grade 1 and 2 (G1NET and G2NET), and poorly differentiated (grade 3) neuroendocrine carcinoma, subdivided into large cell (G3-LCNEC) and small cell (G3-SCNEC).Results: The age-standardised incidence rate (excluding G3-SCNEC) increased from 2.1/100,000 in 1990 to 4.9/100,000 in 2010. The incidence of G1NET increased from 2.0 to 3.0; there was a large increase in G2NET from 0.01 in 1990 to 0.2 in 2010, and of the G3-LCNEC from 0.01 to 1.8, respectively. In G3-SCNEC incidence in men decreased from 21.3 to 10.1, whereas in women it increased from 4.5 to 7.7. The 5-year survival improved in G1NET, particularly for metastatic disease, from 30% in 1990-2000 to 47% in 2001-2010.Conclusion: The increasing incidence of NET (without G3-SCNEC) was mainly due to the increase of G3-LCNEC. This increase is related to improved diagnostic procedures and to shifting in pathology from other entities (such as undifferentiated carcinoma) to NET. Improved survival was seen in all sites and stages, especially in patients with metastatic G1NET. Because of its influence on incidence and survival, we recommend to present epidemiological studies on NET according to histological classification. (C) 2013 Published by Elsevier Ltd.