Steric tuning of the amidomonophosphane-rhodium(I) catalyst in asymmetric addition of arylboroxines to N-phosphinoyl aldimines.
Steric tuning of the amidomonophosphane-rhodium(I) catalyst in asymmetric addition of arylboroxines to N-phosphinoyl aldimines.
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DOI：
10.1021/ol901866y
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发表时间：
2009-09
期刊：
影响因子：
5.2
通讯作者：
Xinyu Hao;M. Kuriyama;Qian Chen;Y. Yamamoto;Ken‐ichi Yamada;K. Tomioka
中科院分区：
文献类型：
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作者：
Xinyu Hao;M. Kuriyama;Qian Chen;Y. Yamamoto;Ken‐ichi Yamada;K. Tomioka
通过将二苯基磷部分与手性酰胺单膦的二(邻甲苯基)磷部分进行空间调节，实现了芳基环硼氧烷与N-膦酰醛亚胺的高度对映选择性铑催化加成。 MS 4 A 在二恶烷-丙醇 5:1 溶剂混合物中的存在对于以高产率提供相应的二芳基甲基胺至关重要。
Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-phosphinoylaldimines was realized by the steric tuning of a diphenylphosphorus moiety to a di(o-tolyl)phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding diarylmethylamines in high yield.