Diffusion anisotropy measurements in ischaemic stroke of the human brain
Diffusion anisotropy measurements in ischaemic stroke of the human brain
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DOI：
10.1016/s1352-8661(98)00007-6
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发表时间：
1998-08-01
影响因子：
2.3
通讯作者：
Cannon, J.
中科院分区：
文献类型：
--
作者：
Armitage, P. A.;Bastin, M. E.;Cannon, J.
对12例出现急性缺血性卒中症状（发作后1-6天）的患者进行磁共振弥散成像。表观扩散系数（ADC）和扩散各向异性测量缺血和对侧正常区域。在缺血区域，ADC测量值降低了约40%，平均卒中与正常的比值为0.56 +/- 0.04（p < 0.0001）。使用标准差和体积比各向异性指数，显示缺血区域的各向异性测量值显著增加，卒中与正常比值分别为1.78 +/- 0.27（p = 0.003）和0.87 +/- 0.05（p = 0.005）。梯度相互作用，图像配准，噪声污染和旋转方差的影响，并在这项研究中得到的结果进行了讨论。(C)1998 Elsevier Science B. V.保留所有权利。
Magnetic resonance diffusion imaging was performed on 12 patients presenting with symptoms of acute ischaemic stroke (1-6 days post-ictus). Apparent diffusion coefficient (ADC) and diffusion anisotropy measurements were obtained from ischaemic and contralateral normal regions. ADC measurements were decreased by around 40% in ischaemic regions, indicated by an average stroke to normal ratio of 0.56 +/- 0.04 (p < 0.0001). The measured anisotropy was shown to be significantly increased in ischaemic regions, using both standard deviation and volume ratio anisotropy indices, which gave stroke to normal ratios of 1.78 +/- 0.27 (p = 0.003) and 0.87 +/- 0.05 (p = 0.005) respectively. The effects of gradient interactions, image registration, noise contamination and rotational variance and their implications for the results obtained in this study are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.