Microglia as modulators of cognition and neuropsychiatric disorders
Microglia as modulators of cognition and neuropsychiatric disorders
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DOI：
10.1002/glia.22372
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发表时间：
2013-01-01
期刊：
影响因子：
6.2
通讯作者：
Prinz, Marco
中科院分区：
文献类型：
--
作者：
Blank, Thomas;Prinz, Marco
最近才变得明显的是，小胶质细胞不仅负责脑中的免疫调节功能，而且代表更大的突触形成的重要组成部分，其还包括突触前和突触后神经元以及星形胶质细胞。小胶质细胞通过其在吞噬细胞碎片、释放多种细胞信号传导因子（包括神经营养因子和细胞外基质组分）以及与神经元直接接触中的作用而对CNS稳态做出关键贡献。这篇综述的目的是总结我们目前对小胶质细胞参与认知过程和神经精神疾病（包括精神分裂症、双相情感障碍、抑郁症和Rett综合征）的认识，并概述其在此背景下的潜在信号传导机制。(c)2012Wiley Periodicals，Inc.
It has become evident recently only that microglia are not only responsible for immunomodulatory functions in the brain but represent vital components of the larger synaptic formation, which also includes pre and postsynaptic neurones as well as astrocytes. Microglia critically contribute to CNS homeostasis by their actions in phagocytosis of cellular debris, release of a variety of cell signaling factors including neurotrophins and extracellular matrix components and direct contact with neurons. The purpose of this review is to summarize our current understanding of the involvement of microglia in cognitive processes and neuropsychiatric disorders including schizophrenia, bipolar disorder, depression, and Rett syndrome and to outline their potential signaling mechanisms in this context. (c) 2012Wiley Periodicals, Inc.