A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation.
A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation.
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DOI：
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发表时间：
2009-03
影响因子：
3.7
通讯作者：
K. Masuko;M. Murata;N. Suematsu;K. Okamoto;K. Yudoh;Hiroshi Nakamura;Tomohiro Kato
中科院分区：
文献类型：
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作者：
K. Masuko;M. Murata;N. Suematsu;K. Okamoto;K. Yudoh;Hiroshi Nakamura;Tomohiro Kato
骨关节炎（OA）被认为与肥胖和身体脂肪量有关。然而，最近的研究旨在阐明脂肪组织衍生蛋白和多种脂质介质（包括脂肪酸、鞘脂和类二十烷酸）在OA软骨降解中的作用，以及体重本身的影响。在这里，我们回顾了OA研究的最新进展，重点关注脂质介质在关节软骨中的潜在作用，并介绍了“OA是一种代谢性疾病”的概念，其中脂质本质上有助于软骨降解的病理生理。
Osteoarthritis (OA) is considered to be linked to obesity and body fat mass. Recent investigations, however, are aimed at clarifying the roles of adipose tissue-derived proteins and a wide variety of lipid mediators, including fatty acids, sphingolipids, and eicosanoids, in cartilage degradation in OA, in addition to the effects body weight itself. Here, we review recent progress in studies of OA, focusing on the potential role of lipid mediators in articular cartilage and introducing the concept that "OA is a metabolic disease" in which lipids essentially contribute to the pathophysiology of cartilage degradation.