Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents
Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents
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DOI：
10.1002/adhm.202001596
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发表时间：
2020-12-16
影响因子：
10
通讯作者：
Choi, Hongsoo
中科院分区：
文献类型：
--
作者：
Choi, Junhee;Hwang, Junsun;Choi, Hongsoo
药物和细胞等治疗剂在几乎所有损伤、疾病或疾病的治疗中都发挥着重要作用。然而，传统的药物递送实践常常会因药物过量和脱靶递送而导致不良副作用。在细胞递送的情况下，移植细胞的存活率极低，并且细胞给药途径的困难仍然是一个问题。最近，磁驱动微型机器人由于其微小的尺寸和以微创方式接近难以到达的病变的能力，开始为靶向治疗提供独特的机会；过去十年来，这方面取得了相当大的进展。在这里，介绍了为靶向药物/细胞递送而开发的磁驱动微型机器人的最新进展，重点是其设计特征和控制治疗释放的机制。此外，还讨论了微型机器人面临的实际挑战以及微型机器人快速从实验室到临床的未来研究方向。
Therapeutic agents, such as drugs and cells, play an essential role in virtually every treatment of injury, illness, or disease. However, the conventional practices of drug delivery often result in undesirable side effects caused by drug overdose and off-target delivery. In the case of cell delivery, the survival rate of the transplanted cells is extremely low and difficulties with the administration route of cells remain a problem. Recently, magnetically actuated microrobots have started offering unique opportunities in targeted therapeutic delivery due to their tiny size and ability to access hard-to-reach lesions in a minimally invasive manner; considerable advances in this regard have been made over the past decade. Here, recent progress in magnetically actuated microrobots, developed for targeted drug/cell delivery, is presented, with a focus on their design features and mechanisms for controlled therapeutic release. Additionally, the practical challenges faced by the microrobots, and future research directions toward the swift bench-to-bedside translation of the microrobots are addressed.