Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment-Elevation Myocardial Infarction
Plasma Trimethylamine N-Oxide as a Novel Biomarker for Plaque Rupture in Patients With ST-Segment-Elevation Myocardial Infarction
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DOI：
10.1161/circinterventions.118.007281
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发表时间：
2019-01-01
影响因子：
5.6
通讯作者：
Yan, Hongbing
中科院分区：
文献类型：
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作者：
Tan, Yu;Sheng, Zhaoxue;Yan, Hongbing
背景技术背景：氧化三甲胺（Trimethylamine N-oxide，TMAO）是一种促进动脉粥样硬化的药物，与心血管事件的发生密切相关。目前尚不清楚血浆TMAO是否与急性心肌梗死患者的斑块形态有关。我们研究了罪犯斑块形态和血浆TMAO浓度与ST段抬高型心肌梗死患者之间的关系。方法和结果：一个前瞻性系列的211例ST段抬高型心肌梗死患者进行干预前光学相干断层扫描检查的罪犯病变入组; 77和69例患者被归类为斑块破裂和斑块糜烂，分别。采用稳定同位素稀释液相色谱串联质谱法检测的血浆TMAO水平，斑块破裂患者显著高于斑块糜烂患者（3.33 μ M;四分位距：2.48 - 4.57 vs 1.21 μ M;四分位距：0.86-1.91; P
BACKGROUND: Trimethylamine N-oxide (TMAO) is reported to promote the pathogenesis of atherosclerosis and be associated with cardiovascular events risk. It is unknown whether plasma TMAO is associated with plaque morphology in patients with acute myocardial infarction. We investigated the relationship between the culprit plaque morphology and plasma TMAO concentration in patients with ST-segment-elevation myocardial infarction.METHODS AND RESULTS: A prospective series of 211 patients with ST-segment-elevation myocardial infarction who underwent preintervention optical coherence tomography examination for the culprit lesion were enrolled; 77 and 69 patients were categorized as plaque rupture and plaque erosion, respectively. Plasma TMAO levels, detected using stable isotope dilution liquid chromatography tandem mass spectrometry, were significantly higher in patients with plaque rupture than in those with plaque erosion (3.33 mu M; interquartile range: 2.484.57 versus 1.21 mu M; interquartile range: 0.86-1.91; P