The importance of urinary immunoglobulin light chain isoelectric point (pI) in nephrotoxicity in multiple myeloma.
The importance of urinary immunoglobulin light chain isoelectric point (pI) in nephrotoxicity in multiple myeloma.
复制标题
尿免疫球蛋白轻链等电点 (pI) 在多发性骨髓瘤肾毒性中的重要性。
DOI：
10.1042/cs0660229
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发表时间：
1984
期刊：
影响因子：
6
通讯作者：
E. L. Robinson
中科院分区：
文献类型：
--
作者：
R. A. Coward;I. Delamore;Netar P. Mallick;E. L. Robinson
有临床和实验证据表明，尿免疫球蛋白轻链具有肾毒性，但一些患者多年来大量服用，对肾脏几乎没有损害。动物实验表明，如果轻链具有较高的等电点(即与尿液pH值有关的阳离子)，那么它对肾脏的毒性更大。对23例多发性骨髓瘤患者进行了轻链排泄率、轻链等电点(PI)和肌酐清除率的测定。轻链排泄率与轻链等电点无关，与肌酐清除率无关。轻链等电点与肌酐清除率相关，提示这一特性可能是这些免疫球蛋白成分的肾毒性作用的重要决定因素。
There is clinical and experimental evidence to imply that urinary immunoglobulin light chains are nephrotoxic yet some patients pass large amounts for years with little renal damage. Animal experiments suggest that a light chain is more nephrotoxic if it has a high isoelectric point (i.e. is cationic in relation to urine pH). We studied 23 patients with multiple myeloma, measuring light chain excretion rate, light chain isoelectric point (pI) and creatinine clearance. Light chain excretion rate was independent of light chain isoelectric point and did not correlate with creatinine clearance. Light chain isoelectric point correlated with creatinine clearance, suggesting that this characteristic may be an important determinant of the nephrotoxic effect of these immunoglobulin constituents.