Recent advances on the non-coherent band surgery model for site-specific recombination
Recent advances on the non-coherent band surgery model for site-specific recombination
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DOI：
10.1090/conm/746/15004
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发表时间：
2018-10
期刊：
影响因子：
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通讯作者：
Allison H. Moore;M. Vázquez
中科院分区：
文献类型：
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作者：
Allison H. Moore;M. Vázquez
位点特异性重组是一种酶促过程，其中具有精确序列和方向的两个位点沿沿着一个环聚集在一起，被切割，并且末端重组。在打结的底物上的位点特异性重组产生另一个结或双组分连接，这取决于重组前位点的相对取向。在数学上，位点特异性重组被建模为相干（结到连接）或非相干（结到结）条带。在这里，我们调查最近的事态发展，在研究非连贯的带状结，并讨论生物学意义。
Site-specific recombination is an enzymatic process where two sites of precise sequence and orientation along a circle come together, are cleaved, and the ends are recombined. Site-specific recombination on a knotted substrate produces another knot or a two-component link depending on the relative orientation of the sites prior to recombination. Mathematically, site-specific recombination is modeled as coherent (knot to link) or non-coherent (knot to knot) banding. We here survey recent developments in the study of non-coherent bandings on knots and discuss biological implications.