Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in invasive isolates from southern and eastern Mediterranean countries
Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in invasive isolates from southern and eastern Mediterranean countries
复制标题
DOI：
10.1093/jac/dkm365
复制
发表时间：
2007-12-01
影响因子：
5.2
通讯作者：
Grundmann, Hajo
中科院分区：
文献类型：
--
作者：
Borg, Michael A.;de Kraker, Marlieke;Grundmann, Hajo
目的：为了遏制耐甲氧西林金黄色葡萄球菌（MRSA）的日益蔓延，需要有效的流行病学信息。然而，对地中海南部和东部国家情况的了解是不完整的，因为报告是零星的，很难比较。方法：从2003年至2005年，ARMed项目收集了超过36个月的时间内，5000多个侵袭性分离株的敏感性试验结果。金黄色葡萄球菌从血液培养中常规处理的实验室内参与服务62家医院位于阿尔及利亚，塞浦路斯，埃及，约旦，黎巴嫩，马耳他，摩洛哥，突尼斯和Turkis.Results：总体而言，中位MRSA比例为39%（四分位数范围：27.1%至51.1%）。约旦、埃及和塞浦路斯报告的MRSA比例最高，超过50%的侵袭性分离株对甲氧西林耐药。相当大的变化被确定在同一national.Conclusions医院内的MRSA的比例：它似乎是在地中海地区的大多数国家正在经历MRSA感染的激增。这就需要更加重视确定耐药性的相关驱动因素，并采取有效措施加以解决，特别是改进感染控制和抗生素消费做法。
Objectives: Efforts aimed at curtailing the ever increasing spread of methicillin-resistant Staphylococcus aureus (MRSA) require effective information of its epidemiology. However, knowledge about the situation in southern and eastern countries of the Mediterranean is incomplete since reports have been sporadic and difficult to compare.Methods: Over a 36 month period from 2003 to 2005, the ARMed project collected more than 5000 susceptibility test results of invasive isolates of S. aureus from blood cultures routinely processed within participating laboratories servicing 62 hospitals situated in Algeria, Cyprus, Egypt, Jordan, Lebanon, Malta, Morocco, Tunisia and Turkey.Results: Overall, the median MRSA proportion was 39% (interquartile range: 27.1% to 51.1%). The highest proportions of MRSA were reported by Jordan, Egypt and Cyprus, where more than 50% of the invasive isolates were methicillin-resistant. Considerable variation was identified in the proportion of MRSA in hospitals within the same country.Conclusions: It appears that most of the countries in the Mediterranean region are experiencing a surge in MRSA infections. This requires a greater focus to identify relevant drivers of resistance and implement effective practices in order to address them, especially improved infection control and antibiotic consumption practices.