Hydroxylation of aromatic compounds by reduced nicotinamide-adenine dinucleotide and phenazine methosulphate requires hydrogen peroxide and hydroxyl radicals, but not superoxide.

Hydroxylation of aromatic compounds by reduced nicotinamide-adenine dinucleotide and phenazine methosulphate requires hydrogen peroxide and hydroxyl radicals, but not superoxide.
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还原型烟酰胺腺嘌呤二核苷酸和吩嗪硫酸甲酯对芳香族化合物进行羟基化需要过氧化氢和羟​​基自由基,但不需要超氧化物。

DOI:
10.1042/bj1670317
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发表时间:
1977
期刊:
The Biochemical journal
影响因子:
--
通讯作者:
B. Halliwell
B. Halliwell
中科院分区:
--
文献类型:
--
作者:
B. Halliwell

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1. A mixture of NADH and phenazine methosulphate hydroxylates aromatic compounds at acidic pH values. 2. Hydroxylation is inhibited by catalase and by scavengers of the hydroxyl radical (-OH) but not by superoxide dismutase. 3. It is concluded that neither O2 leads to nor HO2- is sufficiently reactive to hydroxylate aromatic rings.