Association of antioxidants with memory in a multiethnic elderly sample. Using the Third National Health and Nutrition Examination Survey
Association of antioxidants with memory in a multiethnic elderly sample. Using the Third National Health and Nutrition Examination Survey
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DOI：
10.1093/oxfordjournals.aje.a009915
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发表时间：
1999-07-01
影响因子：
5
通讯作者：
Hui, SL
中科院分区：
文献类型：
--
作者：
Perkins, AJ;Hendrie, HC;Hui, SL
氧化应激既与衰老过程有关，也与阿尔茨海默病相关的病理变化有关。抗氧化剂在体外被证明可以减少氧化应激，它可能代表了一系列潜在的可修改的保护因素，用于治疗记忆力低下，这是痴呆障碍的主要组成部分。作者在美国一个多民族的老年样本中调查了血清抗氧化剂(维生素E、C、A、类胡萝卜素、硒)水平与记忆力低下之间的关系。样本包括4809名非西班牙裔白人、非西班牙裔黑人和墨西哥裔美国老年人，他们在1988年至1994年进行的第三次全国健康和营养检查调查期间访问了流动检查中心。记忆力的评估使用延迟回忆(一个故事中的六分和三个单词)，记忆力差的定义是综合得分小于4。在调整了年龄、教育程度、收入、血管风险因素以及其他微量元素和矿物质后，每单位胆固醇的血清维生素E水平下降与记忆力低下水平的增加一致相关。在这项研究中，血清维生素A和维生素C、β-胡萝卜素和硒的水平与记忆力减退无关。
Oxidative stress has been implicated both in the aging process and in the pathological changes associated with Alzheimer's disease. Antioxidants, which have been shown to reduce oxidative stress in vitro, may represent a set of potentially modifiable protective factors for poor memory, which is a major component of the dementing disorders. The authors investigated the association between serum antioxidant (vitamins E, C, A, carotenoids, selenium) levels and poor memory performance in an elderly, multiethnic sample of the United States. The sample consisted of 4,809 non-Hispanic White, non-Hispanic Black, and Mexican-American elderly who visited the Mobile Examination Center during the Third National Health and Nutrition Examination Survey, a national cross-sectional survey conducted from 1988 to 1994. Memory is assessed using delayed recall (six points from a story and three words) with poor memory being defined as a combined score less than 4. Decreasing serum levels of vitamin E per unit of cholesterol were consistently associated with increasing levels of poor memory after adjustment for age, education, income, vascular risk factors, and other trace elements and minerals. Serum levels of vitamins A and C, beta-carotene, and selenium were not associated with poor memory performance in this study.