Ventricular arrhythmias during the first year after acute myocardial infarction: influence of long-term treatment with metoprolol.
Ventricular arrhythmias during the first year after acute myocardial infarction: influence of long-term treatment with metoprolol.
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急性心肌梗死后第一年的室性心律失常：美托洛尔长期治疗的影响。
DOI：
10.1161/01.cir.69.6.1129
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发表时间：
1984
期刊：
影响因子：
37.8
通讯作者：
N. Rehnqvist
中科院分区：
文献类型：
--
作者：
G. Olsson;N. Rehnqvist
301例因急性心肌梗死住院的患者，年龄小于70岁，窦性心律，无完全性束分支传导阻滞，出院前根据年龄、梗死面积和6小时心电图（ECG）确定的室性心律失常类型进行分层。此后，他们被随机分配到100 mg bid美托洛尔或安慰剂的双盲治疗。在治疗开始后3天、1个月、6个月和12个月重复记录6小时ECG。在安慰剂组中，复杂性室性早搏（PVC）患者的比例显著增加（即，多形、成对和R-on-T PVC或室性心动过速）以及随访期间患者中PVC数量增加。相比之下，美托洛尔组的PVC数量最初减少（p <0.001），而在整个随访期间继续接受美托洛尔治疗的患者中，PVC的复杂性不变。我们的结论是，作为心肌梗死后自然临床过程的一部分，室性早搏的复杂性和数量的增加可被美托洛尔的长期治疗所抵消。
Three hundred and one patients who had been hospitalized for acute myocardial infarction, were less than 70 years old, were in sinus rhythm, and did not have complete bundle branch block were stratified before discharge according to age, size of infarction, and type of ventricular arrhythmias as determined on a 6 hr electrocardiogram (ECG). They were thereafter randomly assigned to double-blind treatment with 100 mg bid metoprolol or placebo. Repeat 6 hr ECGs were recorded 3 days and 1, 6, and 12 months after treatment had begun. In the placebo group there was a significant increase in the proportion of patients with complex premature ventricular complexes (PVCs) (i.e., multiform, paired and R-on-T PVCs, or ventricular tachycardia) as well as increased numbers of PVCs in the patients during the follow-up. In contrast, an initial decrease in the number of PVCs (p less than .001) was found in the metoprolol group, whereas the complexity of PVCs was constant in those patients who continued on metoprolol therapy throughout the follow-up period. We conclude that the increase in complexity and number of PVCs that is part of the natural clinical course after myocardial infarction is counteracted by long-term treatment with metoprolol.
β-肾上腺素能阻滞药物对实验性心室颤动阈值的比较影响。
DOI：
10.1016/0002-9149(83)90368-5
发表时间：
1983
期刊：
The American journal of cardiology
影响因子：
--
作者：
Anderson,JL;Rodier,HE;Green,LS
通讯作者：
Green,LS