Hypertriglyceridemia is associated with stroke after non-cardiac, non-neurological surgery in the older patients: A nested case-control study.
Hypertriglyceridemia is associated with stroke after non-cardiac, non-neurological surgery in the older patients: A nested case-control study.
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DOI：
10.3389/fnagi.2022.935934
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
老年术后中风是一种罕见但严重的术后并发症。高甘油三酯血症与术后卒中之间的关系仍然存在争议，尤其是在接受非心脏、非神经外科手术的老年患者中。这项研究旨在解决这一临床困境。我们对2015年10月至2021年接受非心脏非神经外科手术的9601例老年患者进行了嵌套式病例对照研究。22例高甘油三酯血症阳性患者的手术类型和手术时间与88例对照组患者的手术类型和时间相匹配，两者的比例为1：4。通过调整各种可能的混杂因素，用条件Logistic回归分析评价高甘油三酯血症对术后30天内发生卒中的影响。术后发生缺血性卒中22例，与非卒中组比较，术后ICU入院时间长，住院总费用高(P均<0.045)，术前高甘油三酯血症发生率高[8例(36.4%)比15例(17.0%)，P=0.045]。高甘油三酯血症与术后卒中显著相关，调整后的优势比为6.618(95%可信区间1.286，34.064)(p=0.024)。上述结果在敏感性分析中保持稳健。在接受非心脏和非神经外科手术的老年患者中，高甘油三酯血症与术后中风风险显著增加相关。
Geriatric postoperative stroke is a rare but serious complication after surgery. The association between hypertriglyceridemia and postoperative stroke remains controversial, especially in older patients undergoing non-cardiac, non-neurological surgery. The study aims to address this clinical dilemma. We conducted a nested case-control study among 9601 aged patients undergoing non-cardiac non-neurological surgery from October 2015 to 2021. A total of 22 positive cases were matched for the surgical type and time, to 88 control patients by a ratio of 1:4. The effect of hypertriglyceridemia on the occurrence of postoperative stroke within 30 days after surgery was estimated using conditional logistic regression analysis by adjusting to various potential confounders. A total of 22 cases developed ischemia stroke after surgery, and compared with the non-stroke group, they had more postoperative ICU admission, longer postoperative hospitalization and higher total cost (all p < 0.05), and more patients were presenting with preoperative hypertriglyceridemia [8 (36.4%) vs. 15 (17.0%), p = 0.045]. There was a significant association between hypertriglyceridemia and postoperative stroke, with adjusted odds ratios of 6.618 (95% CI 1.286, 34.064) (p = 0.024). The above results remained robust in the sensitivity analyses. Among older patients undergoing non-cardiac and non-neurological surgery, hypertriglyceridemia was associated with significant increased risk of postoperative stroke.
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DOI：
10.1016/j.jstrokecerebrovasdis.2016.12.017
发表时间：
2017-07-01
影响因子：
2.5
作者：
Dong, Yi;Cao, Wenjie;Dong, Qiang
通讯作者：
Dong, Qiang
影响因子：
1.6
作者：
Lindberg, A. P.;Flexman, A. M.
通讯作者：
Flexman, A. M.
影响因子：
8.2
作者：
Liang HJ;Zhang QY;Hu YT;Liu GQ;Qi R
通讯作者：
Qi R
影响因子：
5.4
作者：
Kivioja, Reetta;Pietila, Arto;Putaala, Jukka
通讯作者：
Putaala, Jukka
DOI：
10.1056/nejmoa0805002
发表时间：
2008-09-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sacco RL;Diener HC;Yusuf S;Cotton D;Ounpuu S;Lawton WA;Palesch Y;Martin RH;Albers GW;Bath P;Bornstein N;Chan BP;Chen ST;Cunha L;Dahlöf B;De Keyser J;Donnan GA;Estol C;Gorelick P;Gu V;Hermansson K;Hilbrich L;Kaste M;Lu C;Machnig T;Pais P;Roberts R;Skvortsova V;Teal P;Toni D;Vandermaelen C;Voigt T;Weber M;Yoon BW;PRoFESS Study Group
通讯作者：
PRoFESS Study Group