Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery.
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DOI：
10.1155/2012/693083
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发表时间：
2012
影响因子：
4.6
通讯作者：
Muragaki Y
中科院分区：
文献类型：
--
作者：
Gui T;Shimokado A;Sun Y;Akasaka T;Muragaki Y
心血管疾病是发达国家死亡的主要原因，主要是由动脉粥样硬化这种慢性炎症性疾病引起的。巨噬细胞与从血液中招募的单核细胞不同，占动脉粥样硬化斑块中白细胞的大部分。细胞凋亡和凋亡巨噬细胞的清除受到抑制（胞吞作用）与易破裂的斑块有关，这些斑块容易破裂，导致血栓形成。基于巨噬细胞在动脉粥样硬化形成中的核心功能，与巨噬细胞相关或由巨噬细胞产生的细胞因子、趋化因子、酶或microRNA已成为重要的临床预后或诊断生物标志物。本文讨论了单核细胞来源的巨噬细胞在早期动脉粥样硬化形成和晚期疾病中的影响。还描述了巨噬细胞炎症生物标志物的作用和未来可能的发展。
Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis. Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers. This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease. The role and possible future development of macrophage inflammatory biomarkers are also described.
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