Subtype CRF01_AE dominate the sexually transmitted human immunodeficiency virus type 1 epidemic in Guangxi, China
Subtype CRF01_AE dominate the sexually transmitted human immunodeficiency virus type 1 epidemic in Guangxi, China
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CRF01_AE亚型在中国广西1型性传播人类免疫缺陷病毒流行中占主导地位
DOI：
10.1002/jmv.23360
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发表时间：
2013-03-01
影响因子：
12.7
通讯作者：
Li, Jingyun
中科院分区：
文献类型：
--
作者：
Li, Lin;Chen, Lili;Li, Jingyun
广西经性传播的人类免疫缺陷病毒1型（HIV-1）感染呈明显上升趋势。然而，关于HIV-1流行病的遗传特征的资料有限。在这项研究中，HIV-1血清阳性药物初治患者通过异性传播感染入组。对gag和pol基因进行全序列测定，并进行系统发育分析、重组分析和耐药性分析。确定了多种亚型，包括CRF 01_AE（80.1%）、CRF 07_BC（6.4%）、CRF 08_BC（10.2%）、亚型B（1.7%）和URF（1.7%）。在系统发育树中，鉴定了两个大的CRF01_AE簇。一个集群是来自越南的菌株，如以前在静脉注射毒品使用者中报告的那样。其中一个新的类群与福建省的菌株亲缘关系较近。鉴定了CRF 01_AE、亚型B和C之间的亚型间重组。结果表明，广西HIV-1的流行以多重起源的CRF01_AE株为主。J. Med. Virol. 85：388395，2013。(c)2013 Wiley Periodicals，Inc.
Human immunodeficiency virus type 1 (HIV-1) infection by sexual transmission in Guangxi, China had increased dramatically. However, limited information is available on the genetic characterization of the HIV-1 epidemic. In this study, HIV-1 seropositive drug-naive patients infected by heterosexual transmission were enrolled. The full length gag and pol genes were sequenced followed by phylogenetic analysis, recombinant analysis and drug resistant analysis. Multiple subtypes were identified, including CRF01_AE (80.1%), CRF07_BC (6.4%), CRF08_BC (10.2%), subtype B (1.7%), and URFs (1.7%). In the phylogenetic tree, two large CRF01_AE clusters were identified. One cluster is originating from Vietnam strains as being reported previously in intravenous drug users. One novel cluster was identified and showed close relationship to strains from Fujian province. Inter-subtype recombination among CRF01_AE, subtype B and C was identified. Low level drug-resistance in drug-naive heterosexually transmitted infections was found. The results suggested that multiple originating CRF01_AE strains dominated the HIV-1 epidemic in heterosexual transmission in Guangxi province. J. Med. Virol. 85:388395, 2013. (c) 2013 Wiley Periodicals, Inc.