Phase Separation in Asymmetric Cell Division.
Phase Separation in Asymmetric Cell Division.
复制标题
不对称细胞分裂中的相分离。
DOI：
10.1021/acs.biochem.9b00813
复制
发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Wen Wenyu
中科院分区：
文献类型：
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作者：
Wen Wenyu
不对称细胞分裂(ACD)是实现细胞多样性的一种保守策略。细胞可以通过细胞命运决定因素或细胞细胞器的不对称分离来经历内在的ACD。最近，一个新的生物物理概念被称为生物分子相分离，通过它蛋白质和/或RNA通过多价相互作用自主地形成高度集中的非膜封闭的隔室，为许多无膜或膜附着的细胞器的组装和调控提供了新的见解。有趣的是，生物分子相分离被认为是在ACD过程中驱动细胞命运决定因素的不对称缩合以及参与ACD的细胞细胞器的组织。在这个视角下，我首先总结了关于支配内在ACD的分子基础的最新发现。然后我将讨论如何通过相分离形成致密的分子集合体来调节ACD。
Asymmetric cell division (ACD) is a conserved strategy for achieving cell diversity. A cell can undergo an intrinsic ACD through asymmetric segregation of cell fate determinants or cellular organelles. Recently, a new biophysical concept known as biomolecular phase separation, through which proteins and/or RNAs autonomously form a highly concentrated non-membrane-enclosed compartment via multivalent interactions, has provided new insights into the assembly and regulation of many membrane-less or membrane-attached organelles. Intriguingly, biomolecular phase separation is suggested to drive asymmetric condensation of cell fate determinants during ACD as well as organization of cellular organelles involved in ACD. In this Perspective, I first summarize recent findings on the molecular basis governing intrinsic ACD. Then I will discuss how ACD might be regulated by formation of dense molecular assemblies via phase separation.