Oxidative coupling of methylamine with an aminyl radical: direct amidation catalyzed by I2/TBHP with HCl
Oxidative coupling of methylamine with an aminyl radical: direct amidation catalyzed by I2/TBHP with HCl
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DOI：
10.1039/c4cc00621f
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Wang, Zhiyong
中科院分区：
文献类型：
--
作者：
Gao, Lingfeng;Tang, Haoming;Wang, Zhiyong
在I-2/TBHP催化剂存在下，在酸性条件下，通过芳基甲胺的sp（3）C-N键和N-取代甲酰胺的sp（2）C-N键的两次断裂，甲胺与氨基自由基氧化偶联生成酰胺.这种不含过渡金属的合成方法为N-取代酰胺的合成提供了一种新的合成工具，并以较高的产率合成了一系列芳基酰胺。
Oxidative coupling of methylamines with an aminyl radical to construct amides was developed in the presence of an I-2/TBHP catalyst under acidic conditions via the two cleavages of the sp(3) C-N bond of aryl-methylamines and the sp(2) C-N bond of N-substituted formamides respectively. This transition-metal-free protocol provides a novel synthetic tool for the construction of N-substituted amides and a series of arylamides can be easily obtained with good yields.