The role of molecular imaging in drug discovery and development
The role of molecular imaging in drug discovery and development
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DOI：
10.1038/sj.clpt.6100467
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发表时间：
2008-02-01
影响因子：
6.7
通讯作者：
Hargreaves, R. J.
中科院分区：
文献类型：
--
作者：
Hargreaves, R. J.
通过在药物发现和开发过程的早期帮助验证新的药物靶点，支持概念验证测试，分子成像生物标志物在增加候选药物成功的可能性方面发挥着越来越重要的作用。通过促进更好和更快的决策，基于分子和机制的失败可以在开发的早期从研究组合中识别和消除，从而将研究工作集中在最佳候选药物和治疗假设上。分子成像可以提高研究前所未有的机制的成本效益，减少周期时间，提高药物管道质量。
Molecular imaging biomarkers are playing an increasingly important role in efforts to increase the probability of success of drug candidates by helping to validate novel drug targets in support of proof-of-concept testing early in the drug discovery and development process. By facilitating better and faster decision-making, molecule and mechanism-based failures can be identified and eliminated from a research portfolio early in development thereby focusing research efforts on the best drug candidates and therapeutic hypotheses. Molecular imaging can be used to improve the cost-effectiveness of studying unprecedented mechanisms, decrease cycle time, and improve drug pipeline quality.