Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptor
Adenosine acts as an inhibitor of lymphoma cell growth: a major role for the A3 adenosine receptor
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DOI：
10.1016/s0959-8049(00)00130-1
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发表时间：
2000-07-01
影响因子：
8.4
通讯作者：
Multani, AS
中科院分区：
文献类型：
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作者：
Fishman, P;Bar-Yehuda, S;Multani, AS
在这项研究中，我们展示了探索低剂量腺苷对淋巴瘤细胞生长的抑制作用的几种机制。腺苷是一种存在于血浆和其他细胞外液中的嘌呤核苷，通过与 G 蛋白相关的细胞表面受体 A1、A2 和 A3 结合，充当调节分子。最近我们发现肌肉细胞释放的低剂量腺苷可以抑制肿瘤细胞的生长，从而导致肌肉转移的罕见。在目前的工作中，证明了腺苷对 Nb2-11C 大鼠淋巴瘤细胞系增殖的细胞抑制作用。这种效应是通过诱导细胞周期停滞在 G0/G1 期并减少这些细胞中的端粒信号来介导的。人们发现腺苷主要通过与其A3受体结合来发挥其抗增殖作用。通过 A3 腺苷受体介导的细胞抑制抗癌活性使其成为抗癌疗法开发的潜在靶点。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
In this study, we demonstrated several mechanisms exploring the inhibitory effect of low-dose adenosine on lymphoma cell growth. Adenosine, a purine nucleoside present in plasma and other extracellular fluids, acts as a regulatory molecule, by binding to G-protein associated cell-surface receptors, A1, A2 and A3. Recently we showed that low-dose adenosine released by muscle cells, inhibits tumour cell growth and thus attributes to the rarity of muscle metastases. In the present work, a cytostatic effect of adenosine on the proliferation of the Nb2-11C rat lymphoma cell line was demonstrated. This effect was mediated through the induction of cell cycle arrest in the G0/G1 phase and by decreasing the telomeric signal in these cells. Adenosine was found to exert its antiproliferative effect mainly through binding to its A3 receptor. The cytostatic anticancer activity, mediated through the A3 adenosine receptor, turns it into a potential target for the development of anticancer therapies. (C) 2000 Elsevier Science Ltd. All rights reserved.