The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1
The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1
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DOI：
10.1007/s13238-012-2021-x
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发表时间：
2012-04
期刊：
影响因子：
21.1
通讯作者：
Shuai Wang;Jing Long;C. Zheng
中科院分区：
文献类型：
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作者：
Shuai Wang;Jing Long;C. Zheng
1 型单纯疱疹病毒 (HSV-1) 是一种常见的人类病原体，可引起唇疱疹甚至更严重的疾病。原发性上皮感染后，它可以在感觉神经节中建立潜伏期，并响应压力或阳光而重新激活。先前的研究表明，病毒立即早期蛋白ICP0在调节裂解感染和潜伏感染之间的平衡中发挥着关键作用。最近，已确定早幼粒细胞白血病 (PML) 核体 (NB)（小的核亚结构）在缺乏功能性 ICP0 的情况下有助于抑制 HSV-1 感染。在这篇综述中，我们讨论了 ICP0 和 PML NB 之间相互作用的基本原理，表明 PML NB 和 ICP0 在调节 HSV-1 的裂解和潜伏感染方面存在潜在联系。
Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.