Physiology and Treatment of Retained Fetal Membranes in Cattle
Physiology and Treatment of Retained Fetal Membranes in Cattle
复制标题
DOI：
10.1111/j.1939-1676.2010.0473.x
复制
发表时间：
2010-03-01
影响因子：
2.6
通讯作者：
Scherzer, J.
中科院分区：
文献类型：
--
作者：
Beagley, J. C.;Whitman, K. J.;Scherzer, J.
牛胎膜残留对生育和生产有不利影响。了解RFM的病理生理学和病因对于治疗这种疾病很重要。导致正常胎盘分离的激素过程是多因素的，在分娩前就开始了。各种危险因素，包括早产或引产、难产、激素失衡和免疫抑制，都可能中断这些正常的过程，并导致胎盘滞留。目前的研究并不支持许多常用的RFM治疗方法的疗效。全身应用抗生素对治疗RFM后的子宫炎是有益的，但尚未证明抗生素应用能显著改善患有RFM的奶牛未来的繁殖力。胶原酶被注射到残留胎盘的脐动脉中，特异性地针对胎盘蛋白分解的缺乏，并可能促进胎盘的释放。然而，这种疗法成本高昂，其在改善后续生殖功能方面的益处尚未得到评估。
Retained fetal membranes (RFM) in cattle have adverse effects on fertility and production. Understanding the pathophysiology and causes of RFM is important for managing this disease. The hormonal processes that lead to normal placental separation are multifactorial and begin before parturition. A variety of risk factors, including early or induced parturition, dystocia, hormonal imbalances, and immunosuppression, can interrupt these normal processes and result in retention of the placenta. Current research does not support the efficacy of many commonly practiced treatments for RFM. Systemic administration of antibiotics can be beneficial for treating metritis after RFM, but antibiotic administration has not been shown to significantly improve future reproduction in cows with RFM. Collagenase injected into the umbilical arteries of retained placentas specifically targets the lack of placentome proteolysis and might enhance placental release. However, such therapy is costly and its benefits in terms of improving subsequent reproductive function have not been evaluated.