Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons.
Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons.
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腺苷受体：放射自显影证据表明它们位于兴奋性神经元的轴突末端。
DOI：
10.1126/science.6302841
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Snyder,SH
中科院分区：
文献类型：
--
作者：
Goodman,RR;Kuhar,MJ;Hester,L;Snyder,SH
用氚化环己基腺苷放射自显影法在光镜下可见腺苷受体。在小脑中，Weaver小鼠缺乏颗粒细胞，腺苷受体缺失，Reeler小鼠有颗粒细胞移位。因此，腺苷受体似乎位于小脑兴奋性颗粒细胞的轴突末端。切除一只大鼠对侧上丘中耗尽的腺苷受体的一只眼睛，表明受体发生在视网膜神经节细胞兴奋性投射的轴突末端。腺苷受体在兴奋性轴突末端的存在可以解释腺苷的突触抑制和黄嘌呤的行为效应。
Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.