Exploring Rapid, Sensitive and Reliable Detection of Trace Explosives Using Paper Spray Mass Spectrometry (PS-MS)
Exploring Rapid, Sensitive and Reliable Detection of Trace Explosives Using Paper Spray Mass Spectrometry (PS-MS)
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DOI：
10.1002/prep.201800320
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发表时间：
2019-08-01
影响因子：
1.8
通讯作者：
Bailey, Melanie J.
中科院分区：
文献类型：
--
作者：
Costa, Catia;van Es, Elsje M.;Bailey, Melanie J.
在本出版物中，我们致力于使用纸喷雾质谱仪对棉签上收集的爆炸性化合物进行快速、灵敏和选择性的分析。我们已(A)将纸张喷雾基材的尺寸增加至1.6x2.1厘米，以适应目前对爆炸性材料进行擦拭的做法；(B)开发了一种确定从基材中成功提取分析物的方法，以减少假阴性事件；以及(C)扩大了使用纸张喷雾可以检测到的分析物的范围，包括过氧化氢炸药HMTD，以及硝化甘油(NG)、苦味酸(PA)和叔丁。我们报道了一种30 S的方法，用PS-MS同时检测7种不同的爆炸性物质，检出限低于25pg，以及对2500pg的HMTD的检测，比以前发表的工作有所改进。
In this publication we work towards providing fast, sensitive and selective analysis of explosive compounds collected on swabs using paper spray mass spectrometry. We have (a) increased the size of the paper spray substrate to 1.6x2.1 cm for compatibility with current practise in swabbing for explosive material; (b) developed a method for determining a successful extraction of analyte from the substrate to reduce false negative events; and (c) expanded the range of analytes that can be detected using paper spray to include the peroxide explosive HMTD, as well as nitroglycerine (NG), picric acid (PA) and tetryl. We report the development of a 30 s method for the simultaneous detection of 7 different explosive materials using PS-MS with detection limits below 25 pg, as well as detection of HMTD at 2500 pg, showing an improvement on previously published work.