Morphology and epidermal thickness of normal skin imaged by optical coherence tomography
Morphology and epidermal thickness of normal skin imaged by optical coherence tomography
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DOI：
10.1159/000118508
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发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Jemec, Gregor B. E.
中科院分区：
文献类型：
--
作者：
Mogensen, Mette;Morsy, Hanan A.;Jemec, Gregor B. E.
背景：光学相干断层扫描（OCT）是一种具有非侵入性皮肤癌诊断潜力的光学成像技术。为了使用OCT识别皮肤病变，建立正常皮肤的基线形态学特征是至关重要的。目的：本研究的目的是利用OCT和偏振敏感OCT （PS-OCT）来描述正常皮肤形态，偏振敏感OCT是一种在OCT图像中表示双折射组织（如胶原蛋白）的方法。对20名健康志愿者的解剖位置进行成像，测量表皮厚度（ET），并将其与年龄、性别和肤色进行比较。方法：基于组织的红外光反射/背散射成像。PS-OCT检测组织双折射。对12个皮肤区域进行影像学检查。根据OCT图像计算ET。结果：正常皮肤呈层状结构。成人的分层现象不那么明显。无毛皮肤可见角质层。儿童ET较大（p < 0.0001）。年龄与ET呈负相关（p < 0.05）。ET没有发现性别或皮肤类型相关的差异。结论：本研究有助于理解正常皮肤的OCT和PS-OCT图像，表明OCT可用于皮肤的定性和定量评估。版权所有2008 S. Karger AG，巴塞尔
Background: Optical coherence tomography (OCT) is an optical imaging technology with a potential in the non-invasive diagnosis of skin cancer. To identify skin pathologies using OCT, it is of prime importance to establish baseline morphological features of normal skin. Aims: The aim of this study is to describe normal skin morphology using OCT and polarization-sensitive OCT (PS-OCT), which is a way of representing birefringent tissue such as collagen in OCT images. Anatomical locations in 20 healthy volunteers were imaged, and epidermal thickness (ET) was measured and compared to age, gender and skin colour. Methods: OCT imaging is based on infrared light reflection/backscatter from tissue. PS-OCT detects birefringence of tissue. Imaging was performed in 12 skin regions. ET was calculated from the OCT images. Results: Normal skin has a layered structure. Layering is less pronounced in adults. In glabrous skin the stratum corneum is visible. Children had larger ET (p < 0.0001). Age had a negative correlation with ET (p < 0.05). No gender- or skin-type-related differences in ET were found. Conclusion: This study contributes to understanding OCT and PS-OCT images of normal skin and indicates that OCT can be used for both the qualitative and quantitative assessment of skin. Copyright (C) 2008 S. Karger AG, Basel.