Primary lymphoma of the central nervous system. Clinicopathological study of experience at Stanford.
Primary lymphoma of the central nervous system. Clinicopathological study of experience at Stanford.
复制标题
中枢神经系统原发性淋巴瘤。
作者：
T. Helle;R. Britt;T. Colby
作者报告了斯坦福大学医学中心22例原发性中枢神经系统淋巴瘤。其他15个发表的系列，包括400例这种疾病的患者也进行了审查。男性比女性更容易受到影响。大多数患者年龄在60岁左右。最常见的症状是头痛、恶心、呕吐和精神状态改变。最常见的表现是轻偏瘫和视神经乳头水肿。蛋白浓度升高是最常见的脑脊液（CSF）异常。手术前CSF细胞学很少呈阳性。如果在计算机断层扫描上看到肿块，则总是通过注入造影剂来增强。在血管造影，肿瘤通常被视为一个无血管的肿块。最常见和最不常见的网站涉及幕上额叶和枕叶，分别。小脑最常受累。组织学上，根据Rappaport和工作分类系统，最常见的组织类型分别为弥漫性组织细胞淋巴瘤和免疫母细胞淋巴瘤。治疗主要涉及手术活检或次全切除和放射治疗。大多数患者死亡，死亡患者的中位生存时间明显短于仍存活患者的随访时间。这种生存时间的差异表明，原发性CNS淋巴瘤包括一个以上的疾病组。我们的统计分析显示，无论是弥漫性混合淋巴瘤组织学或幕下病变部位的患者预后较差。这两个因素不能完全解释将病例分为单独的生存相关组的原因。
The authors present 22 cases of primary lymphoma of the central nervous system (CNS) from Stanford University Medical Center. Fifteen other published series comprising 400 patients with this disease are also reviewed. Males were affected more often than females. The majority of patients were in the sixth decade of life. The most common presenting symptoms were headache, nausea, vomiting, and mental status changes. The most common presenting signs were hemiparesis and papilledema. An elevated protein concentration was the most common cerebrospinal fluid (CSF) abnormality. The CSF cytology was rarely positive prior to surgery. If a mass was seen on computerized tomography, it always enhanced with infusion of contrast material. On angiography, the tumor was generally seen as an avascular mass. The most and least common sites of involvement supratentorially were the frontal and occipital lobes, respectively. Infratentorially, the cerebellum was most often involved. Histologically, the most common tissue type according to the Rappaport and Working Formulation systems were diffuse histiocytic lymphoma and immunoblastic lymphoma, respectively. Therapy primarily involved surgery for biopsy or subtotal resection and radiation therapy. The majority of patients died, and the median survival time of those dying was distinctly shorter than the follow-up period of those patients still alive. This difference in survival time suggests that primary CNS lymphoma consists of more than one disease group. Statistical analysis of our series showed those patients with either a diffuse mixed lymphoma histology or an infratentorial location of disease had a poorer prognosis. These two factors cannot totally account for the division of cases into separate survival-related groups.
用甲氨蝶呤治疗中枢神经系统肿瘤。
DOI：
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发表时间：
1981
期刊：
Cancer treatment reports
影响因子：
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作者：
Abelson,HT;Kufe,DW;Skarin,AT;Major,P;Ensminger,W;Beardsley,GP;Canellos,GP
通讯作者：
Canellos,GP