Practical Considerations in Breast Papillary Lesions
Practical Considerations in Breast Papillary Lesions
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DOI：
10.5858/arpa.2015-0525-ra
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发表时间：
2016-08-01
影响因子：
4.6
通讯作者：
Hayes, Malcolm M.
中科院分区：
文献类型：
--
作者：
Agoumi, Mehdi;Giambattista, Joshua;Hayes, Malcolm M.
乳房乳头状病变的诊断，特别是在核心活检中，对大多数病理学家来说是具有挑战性的，这些病变给患者的处理带来了问题。乳头状病变的良性、癌前和恶性成分之间的区别是具有挑战性的，在边缘有限制的病变中，侵袭的诊断是有问题的。在这些病变的过度治疗和治疗不足之间取得平衡也是具有挑战性的。目的：提供乳腺乳头状病变的组织学和免疫组织化学特征以及鉴别诊断的分类和描述，提供乳腺乳头状病变的分子病理学的最新进展，并讨论对乳头状乳头状病变的进一步研究和处理的建议。这篇综述简要描述了乳房不同乳头状病变的组织学和免疫组织化学特征。数据来源。-在PubMed数据库(http://www.ncbi.nlm.nih.gov/pubmed).Conclusions.-Knowledge的帮助下，回顾了关于乳腺病理学的标准病理学教科书和关于乳头状腺病的文献，这些文献包括乳头状腺病的临床表现、组织学、免疫学和行为，这将有助于病理学家对乳头状腺病患者的诊断和最佳处理。
Context.-Diagnosis of papillary breast lesions, especially in core biopsies, is challenging for most pathologists, and these lesions pose problems for patient management. Distinction between benign, premalignant, and malignant components of papillary lesions is challenging, and the diagnosis of invasion is problematic in lesions that have circumscribed margins. Obtaining a balance between overtreatment and undertreatment of these lesions is also challenging.Objectives.-To provide a classification and a description of the histologic and immunohistochemical features and the differential diagnosis of papillary breast lesions, to provide an update on the molecular pathology of papillary breast lesions, and to discuss the recommendations for further investigation and management of papillary breast lesions. This review provides a concise description of the histologic and immunohistochemical features of the different papillary lesions of the breast.Data Sources.-The standard pathology text books on breast pathology and literature on papillary breast lesions were reviewed with the assistance of the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed).Conclusions.-Knowledge of the clinical presentation, histology, immunoprofile, and behavior of papillary breast lesions will assist pathologists with the diagnosis and optimal management of patients with papillary breast lesions.