Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders
Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders
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DOI：
10.1038/nn1611
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发表时间：
2006-01-01
影响因子：
25
通讯作者：
Iacoboni, M
中科院分区：
文献类型：
--
作者：
Dapretto, M;Davies, MS;Iacoboni, M
为了研究自闭症患者的镜像神经元异常，高功能自闭症儿童和匹配的对照组在模仿和观察情绪表达时接受了fMRI。尽管两组儿童在完成任务时表现相当，但自闭症儿童的额下回（盖部）没有镜像神经元活动。值得注意的是，这一区域的活动与社交领域的症状严重程度呈负相关，这表明功能失调的“镜像神经元系统”可能是自闭症中观察到的社交缺陷的基础。
To examine mirror neuron abnormalities in autism, high-functioning children with autism and matched controls underwent fMRI while imitating and observing emotional expressions. Although both groups performed the tasks equally well, children with autism showed no mirror neuron activity in the inferior frontal gyrus (pars opercularis). Notably, activity in this area was inversely related to symptom severity in the social domain, suggesting that a dysfunctional 'mirror neuron system' may underlie the social deficits observed in autism.